Detailed biodistribution of liposomes prepared with polyborane instead of cholesterol for BNCT: effects of PEGylation

Detailed biodistribution of liposomes prepared with polyborane instead of cholesterol for BNCT:... Various drug delivery systems for boron neutron capture therapy (BNCT) have been developed. To selectively destroy cancer cells, the high accumulation and selective delivery of 10B into tumor tissue are required. In this study, a polyborane for BNCT with enhanced hydrophobicity was synthesized from decaborane as a boron carrier, and embedded into bare and PEGylated liposomes. These liposomes having diameters of 40–43 nm were injected into tail vein of tumor-bearing mice to evaluate their biodistribution. Boron concentrations in tumor and tumor/blood ratios of the liposomes were reached over 30 μg/g of tissue and over 5 at 8–24 h, respectively. At 12 h after injection, PEGylated liposomes were found in tumor with high boron level (130.0 μg/g of tissue). This result showed that the PEGylated liposomes with a diameter of 40 nm were able to achieve efficient intratumoral 10B amount without replacing the 11B with 10B. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Colloid Polymer Science Springer Journals

Detailed biodistribution of liposomes prepared with polyborane instead of cholesterol for BNCT: effects of PEGylation

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Chemistry; Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Characterization and Evaluation of Materials; Physical Chemistry; Food Science; Nanotechnology and Microengineering
ISSN
0303-402X
eISSN
1435-1536
D.O.I.
10.1007/s00396-017-4113-x
Publisher site
See Article on Publisher Site

Abstract

Various drug delivery systems for boron neutron capture therapy (BNCT) have been developed. To selectively destroy cancer cells, the high accumulation and selective delivery of 10B into tumor tissue are required. In this study, a polyborane for BNCT with enhanced hydrophobicity was synthesized from decaborane as a boron carrier, and embedded into bare and PEGylated liposomes. These liposomes having diameters of 40–43 nm were injected into tail vein of tumor-bearing mice to evaluate their biodistribution. Boron concentrations in tumor and tumor/blood ratios of the liposomes were reached over 30 μg/g of tissue and over 5 at 8–24 h, respectively. At 12 h after injection, PEGylated liposomes were found in tumor with high boron level (130.0 μg/g of tissue). This result showed that the PEGylated liposomes with a diameter of 40 nm were able to achieve efficient intratumoral 10B amount without replacing the 11B with 10B.

Journal

Colloid Polymer ScienceSpringer Journals

Published: Jun 10, 2017

References

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