Desmoid tumor occurrence in female siblings not associated with familial adenomatous polyposis: genetic or sporadic form?

Desmoid tumor occurrence in female siblings not associated with familial adenomatous polyposis:... Eur J Plast Surg (2013) 36:277–280 DOI 10.1007/s00238-012-0777-0 LETTER TO THE EDITOR Desmoid tumor occurrence in female siblings not associated with familial adenomatous polyposis: genetic or sporadic form? Marika Langella & Alfonso Luca Pendolino & Pietro Francesco Delle Femmine & Michelina Maria Carla Amato & Antonella Bianchi & Paolo Persichetti Received: 31 August 2012 /Accepted: 22 October 2012 /Published online: 9 November 2012 Springer-Verlag Berlin Heidelberg 2012 Sir, Nonetheless, causes of DTs are still uncertain. Be- Desmoid tumors (DTs) are rare tumors which belong to sides specific mutations in the APC gene, risk factors heterogenous group of soft tissue tumors. Affected for the development of DTs include even previous sur- patients usually fall within the age range of 10–40 years, gical procedures, pregnancy, and female sex. Trauma in with a higher prevalence among women during their the tumor site may elicit DTs. It seems that the in- fertile period [1]. creased risk after surgery may be due to the activation Desmoids may occur either sporadically or as an of fibroblasts, normally involved in repairing tissue extra-colonic manifestation of familial adenomatous pol- damage [5]. Sporadic DTs are more common in female yposis (FAP). This association was first discovered by than http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Desmoid tumor occurrence in female siblings not associated with familial adenomatous polyposis: genetic or sporadic form?

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Publisher
Springer-Verlag
Copyright
Copyright © 2013 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s00238-012-0777-0
Publisher site
See Article on Publisher Site

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