Keywords Cyclooxygenase-2 Molecular docking HCT-15 MIAPaCa-2 SRB protocol DPPH assay Anti-oxidant and anticancer Introduction Organic syntheses are key tools for supplying rare compounds and are helping in the transformation of bioactive natural compounds into more drug-like deriva- tives [1, 2]. Some novel synthetic tactics have been developed in an effort to yield potential compounds with medicinal value [3–5]. Mainly, structural modiﬁcations of the natural core structures are achieved to increase selectivity and potency to provide other properties [6, 7] and to help their synthesis . In addition, many novel synthetic approaches have been developed to increase structural diversity; in other words, to enlarge the chemical space of investigated molecules [9–11]. Thymol (2-iso-propyl- 5-methylphenol) and its isomer carvacrol (5-iso-propyl-2- methyl-phenol) are the most frequently occurring constituents of thyme plants, which possess a wide range of biological and pharmacological properties [12–14]. The rich essential oils present in thyme species are used for the treatment of several diseases as well as for the preservation of food . These two naturally occurring phenolic monoterpenoids are outstanding resourceful molecules incorporated as functional ingredients in numerous products [16, 17]. Carvacrol and thymol have been used as precursors for the synthesis
Research on Chemical Intermediates – Springer Journals
Published: Mar 8, 2017
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