Design, synthesis, biological screenings and docking simulations of novel carvacrol and thymol derivatives containing acetohydrazone linkage

Design, synthesis, biological screenings and docking simulations of novel carvacrol and thymol... Keywords Cyclooxygenase-2  Molecular docking  HCT-15  MIAPaCa-2 SRB protocol  DPPH assay  Anti-oxidant and anticancer Introduction Organic syntheses are key tools for supplying rare compounds and are helping in the transformation of bioactive natural compounds into more drug-like deriva- tives [1, 2]. Some novel synthetic tactics have been developed in an effort to yield potential compounds with medicinal value [3–5]. Mainly, structural modifications of the natural core structures are achieved to increase selectivity and potency to provide other properties [6, 7] and to help their synthesis [8]. In addition, many novel synthetic approaches have been developed to increase structural diversity; in other words, to enlarge the chemical space of investigated molecules [9–11]. Thymol (2-iso-propyl- 5-methylphenol) and its isomer carvacrol (5-iso-propyl-2- methyl-phenol) are the most frequently occurring constituents of thyme plants, which possess a wide range of biological and pharmacological properties [12–14]. The rich essential oils present in thyme species are used for the treatment of several diseases as well as for the preservation of food [15]. These two naturally occurring phenolic monoterpenoids are outstanding resourceful molecules incorporated as functional ingredients in numerous products [16, 17]. Carvacrol and thymol have been used as precursors for the synthesis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Design, synthesis, biological screenings and docking simulations of novel carvacrol and thymol derivatives containing acetohydrazone linkage

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-017-2919-2
Publisher site
See Article on Publisher Site

Abstract

Keywords Cyclooxygenase-2  Molecular docking  HCT-15  MIAPaCa-2 SRB protocol  DPPH assay  Anti-oxidant and anticancer Introduction Organic syntheses are key tools for supplying rare compounds and are helping in the transformation of bioactive natural compounds into more drug-like deriva- tives [1, 2]. Some novel synthetic tactics have been developed in an effort to yield potential compounds with medicinal value [3–5]. Mainly, structural modifications of the natural core structures are achieved to increase selectivity and potency to provide other properties [6, 7] and to help their synthesis [8]. In addition, many novel synthetic approaches have been developed to increase structural diversity; in other words, to enlarge the chemical space of investigated molecules [9–11]. Thymol (2-iso-propyl- 5-methylphenol) and its isomer carvacrol (5-iso-propyl-2- methyl-phenol) are the most frequently occurring constituents of thyme plants, which possess a wide range of biological and pharmacological properties [12–14]. The rich essential oils present in thyme species are used for the treatment of several diseases as well as for the preservation of food [15]. These two naturally occurring phenolic monoterpenoids are outstanding resourceful molecules incorporated as functional ingredients in numerous products [16, 17]. Carvacrol and thymol have been used as precursors for the synthesis

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Mar 8, 2017

References

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