Design, synthesis, anticancer activity and cytotoxicity of novel 4-piperidone/cyclohexanone derivatives

Design, synthesis, anticancer activity and cytotoxicity of novel 4-piperidone/cyclohexanone... Qin Chen and Yun Hou have contributed equally to this work. & Gui-Ge Hou & Chun-Hua Wang The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, People’s Republic of China 123 8120 Q. Chen et al. Keywords 4-Piperidone  Cyclohexanone  Schiff-base  Anticancer activity Cytotoxicity Introduction Curcumin (Diferuloylmethane, Fig. 1), a member of the curcuminoid family, is the yellow-coloured phenolic pigment of the rhizome of Curcuma longa or turmeric from the Zingiberaceae family. Since antiquity, Curcuma longa or turmeric has been used to improve colour and flavor of food products [1, 2]. More important, curcumin, the active principle of turmeric [3, 4], has been reported to possess anti- inflammatory, anticoagulant, antibacterial, antifungal, anticarcinogenic, antitumor, anti-HIV, anti-mutagenic, antiproliferative, antioxidant, anti-protozoal, and anti- venom activities [5–10]. Curcumin and its analogues containing the pharmacophore of 1,5-diaryl-3-oxo-1,4-pentadienyl, is thought to interact at the primary binding site and bio-thiols from susceptible neoplasms. The pharmacophore of methoxyphenol groups align at an auxiliary site and also influence their bio-activities. However, curcumin and some analogues have many major problems in clinical applications, such as poor aqueous solubility, relatively low bioavailability, Research on Chemical Intermediates Springer Journals

Design, synthesis, anticancer activity and cytotoxicity of novel 4-piperidone/cyclohexanone derivatives

Loading next page...
Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial