Qin Chen and Yun Hou have contributed equally to this work. & Gui-Ge Hou firstname.lastname@example.org & Chun-Hua Wang email@example.com The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, People’s Republic of China 123 8120 Q. Chen et al. Keywords 4-Piperidone Cyclohexanone Schiff-base Anticancer activity Cytotoxicity Introduction Curcumin (Diferuloylmethane, Fig. 1), a member of the curcuminoid family, is the yellow-coloured phenolic pigment of the rhizome of Curcuma longa or turmeric from the Zingiberaceae family. Since antiquity, Curcuma longa or turmeric has been used to improve colour and ﬂavor of food products [1, 2]. More important, curcumin, the active principle of turmeric [3, 4], has been reported to possess anti- inﬂammatory, anticoagulant, antibacterial, antifungal, anticarcinogenic, antitumor, anti-HIV, anti-mutagenic, antiproliferative, antioxidant, anti-protozoal, and anti- venom activities [5–10]. Curcumin and its analogues containing the pharmacophore of 1,5-diaryl-3-oxo-1,4-pentadienyl, is thought to interact at the primary binding site and bio-thiols from susceptible neoplasms. The pharmacophore of methoxyphenol groups align at an auxiliary site and also inﬂuence their bio-activities. However, curcumin and some analogues have many major problems in clinical applications, such as poor aqueous solubility, relatively low bioavailability,
Research on Chemical Intermediates – Springer Journals
Published: May 27, 2016
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