Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based sulfonamide derivatives

Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based... Keywords Carvacrol  Sulfonamide  Aryl sulfonyl hydrazide  Antimicrobial activity  Antioxidant activity Introduction The invention of antibiotics in the twentieth century was a distinct turning point in the treatment of infections. However, the rapid appearance of resistance among pathogens towards the available antibiotics is still a most important cause of death [1, 2]. Many infectious diseases caused by bacteria and fungi have remained a major universal health problem due to the rapid development of resistance to the existing antimicrobial drugs [3]. Hence, there is a fundamental requirement for the search for novel and more effective antimicrobial agents. Sulfonamides are a prominent class of pharmaceutically operational motifs exhibiting a wide variety of biological activities [4, 5] such as antifungal, antibacterial [6], anticarbonic anhydrase [7, 8], high-ceiling diuretic [9], hypoglycemic, antithyroid, anti-inflammatory [10, 11], antiglaucoma, antiviral, antineoplasic, etc. [12]. Furthermore, sulfonamides are energetic functional groups with widespread utility in agriculture, dyes and organic materials [5]. Considering all the activities of this class of compounds, they have been looked at as ‘‘privileged structures’’ in medicinal chemistry [13–15]. They are 123 Design, synthesis and biological activities of novel… 2243 generally used in veterinary medicines for therapeutic purposes to combat bacterial diseases http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based sulfonamide derivatives

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2759-5
Publisher site
See Article on Publisher Site

Abstract

Keywords Carvacrol  Sulfonamide  Aryl sulfonyl hydrazide  Antimicrobial activity  Antioxidant activity Introduction The invention of antibiotics in the twentieth century was a distinct turning point in the treatment of infections. However, the rapid appearance of resistance among pathogens towards the available antibiotics is still a most important cause of death [1, 2]. Many infectious diseases caused by bacteria and fungi have remained a major universal health problem due to the rapid development of resistance to the existing antimicrobial drugs [3]. Hence, there is a fundamental requirement for the search for novel and more effective antimicrobial agents. Sulfonamides are a prominent class of pharmaceutically operational motifs exhibiting a wide variety of biological activities [4, 5] such as antifungal, antibacterial [6], anticarbonic anhydrase [7, 8], high-ceiling diuretic [9], hypoglycemic, antithyroid, anti-inflammatory [10, 11], antiglaucoma, antiviral, antineoplasic, etc. [12]. Furthermore, sulfonamides are energetic functional groups with widespread utility in agriculture, dyes and organic materials [5]. Considering all the activities of this class of compounds, they have been looked at as ‘‘privileged structures’’ in medicinal chemistry [13–15]. They are 123 Design, synthesis and biological activities of novel… 2243 generally used in veterinary medicines for therapeutic purposes to combat bacterial diseases

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Oct 12, 2016

References

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