Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based sulfonamide derivatives

Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based... Keywords Carvacrol  Sulfonamide  Aryl sulfonyl hydrazide  Antimicrobial activity  Antioxidant activity Introduction The invention of antibiotics in the twentieth century was a distinct turning point in the treatment of infections. However, the rapid appearance of resistance among pathogens towards the available antibiotics is still a most important cause of death [1, 2]. Many infectious diseases caused by bacteria and fungi have remained a major universal health problem due to the rapid development of resistance to the existing antimicrobial drugs [3]. Hence, there is a fundamental requirement for the search for novel and more effective antimicrobial agents. Sulfonamides are a prominent class of pharmaceutically operational motifs exhibiting a wide variety of biological activities [4, 5] such as antifungal, antibacterial [6], anticarbonic anhydrase [7, 8], high-ceiling diuretic [9], hypoglycemic, antithyroid, anti-inflammatory [10, 11], antiglaucoma, antiviral, antineoplasic, etc. [12]. Furthermore, sulfonamides are energetic functional groups with widespread utility in agriculture, dyes and organic materials [5]. Considering all the activities of this class of compounds, they have been looked at as ‘‘privileged structures’’ in medicinal chemistry [13–15]. They are 123 Design, synthesis and biological activities of novel… 2243 generally used in veterinary medicines for therapeutic purposes to combat bacterial diseases Research on Chemical Intermediates Springer Journals

Design, synthesis and biological activities of novel 5-isopropyl-2-methylphenolhydrazide-based sulfonamide derivatives

Loading next page...
Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial