Keywords Carvacrol Sulfonamide Aryl sulfonyl hydrazide Antimicrobial activity Antioxidant activity Introduction The invention of antibiotics in the twentieth century was a distinct turning point in the treatment of infections. However, the rapid appearance of resistance among pathogens towards the available antibiotics is still a most important cause of death [1, 2]. Many infectious diseases caused by bacteria and fungi have remained a major universal health problem due to the rapid development of resistance to the existing antimicrobial drugs . Hence, there is a fundamental requirement for the search for novel and more effective antimicrobial agents. Sulfonamides are a prominent class of pharmaceutically operational motifs exhibiting a wide variety of biological activities [4, 5] such as antifungal, antibacterial , anticarbonic anhydrase [7, 8], high-ceiling diuretic , hypoglycemic, antithyroid, anti-inﬂammatory [10, 11], antiglaucoma, antiviral, antineoplasic, etc. . Furthermore, sulfonamides are energetic functional groups with widespread utility in agriculture, dyes and organic materials . Considering all the activities of this class of compounds, they have been looked at as ‘‘privileged structures’’ in medicinal chemistry [13–15]. They are 123 Design, synthesis and biological activities of novel… 2243 generally used in veterinary medicines for therapeutic purposes to combat bacterial diseases
Research on Chemical Intermediates – Springer Journals
Published: Oct 12, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera