Design, synthesis, and antiviral activity of novel purine derivatives containing 1,4-pentadien-3-one moiety

Design, synthesis, and antiviral activity of novel purine derivatives containing... A series of novel purine derivatives containing 1,4-pentadien-3-one moiety were designed and synthesized. The optimal conditions for the synthesis of the target compounds E 1 –E 25 were as follows: solvent, DMF; catalyst, KOH; temperature, 40 °C; time, 2 h; and molar equivalent of A:D:Catalyst, 1:0.8:1.2. Antiviral bioassays indicated that compounds E 1 , E 3 , E 5 , E 7 , E 18 , and E 19 showed excellent protection activities, with EC50 values of 188.9, 194.6, 125.2, 134.1, 137.8, and 195.4 µg/mL, respectively, which were better than that of Ningnanmycin (271.2 μg/mL). To the best of our knowledge, this study is the first report on the design, synthesis, and antiviral activity of novel purine derivatives containing 1,4-pentadien-3-one moiety. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Design, synthesis, and antiviral activity of novel purine derivatives containing 1,4-pentadien-3-one moiety

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2524-9
Publisher site
See Article on Publisher Site

Abstract

A series of novel purine derivatives containing 1,4-pentadien-3-one moiety were designed and synthesized. The optimal conditions for the synthesis of the target compounds E 1 –E 25 were as follows: solvent, DMF; catalyst, KOH; temperature, 40 °C; time, 2 h; and molar equivalent of A:D:Catalyst, 1:0.8:1.2. Antiviral bioassays indicated that compounds E 1 , E 3 , E 5 , E 7 , E 18 , and E 19 showed excellent protection activities, with EC50 values of 188.9, 194.6, 125.2, 134.1, 137.8, and 195.4 µg/mL, respectively, which were better than that of Ningnanmycin (271.2 μg/mL). To the best of our knowledge, this study is the first report on the design, synthesis, and antiviral activity of novel purine derivatives containing 1,4-pentadien-3-one moiety.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Apr 11, 2016

References

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