Design, synthesis, and antimicrobial activity of novel 5-substituted indole-2-carboxamide derivatives

Design, synthesis, and antimicrobial activity of novel 5-substituted indole-2-carboxamide... Keywords Indole-2-carboxamide  Antibacterial  Antifungal  SAR study Introduction For the normal growth of animals and microbes, the interactions between them are intimate and vital, yet they also have darker side, since microbes trigger a broad range of human diseases. History observes continual battle between human beings and disease-causing microbes. In the field of medicine, invention of and advancements in antibiotics are among the most astonishing achievements of the last century. However, these advances in medical care are threatened by a natural phenomenon known as antimicrobial resistance [1–4]. Antimicrobial resistance is the result of inadequate, empirical, self-medicated, improper, and overuse of antibiotics, a gift of the medical field, for the treatment of diseases. Antibiotic resistance is not new; it is ancient [5]. Infection-causing Gram-negative bacteria, about 50 % of the multidrug- resistant bacteria [6], including Escherichia coli, Pseudomonas aeruginosa,and Acinetobacter baumannii [7], have become a serious threat in hospitals and community clinics [8]. Increasing multidrug-resistant (MDR) infections caused by Gram-negative bacteria are more difficult to treat, since they increase mortality, morbidity [9, 10], and health care cost. In spite of a large number of antibiotics and chemotherapeutics available for medical use, the emergence of multidrug bacterial resistance to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Design, synthesis, and antimicrobial activity of novel 5-substituted indole-2-carboxamide derivatives

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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2696-3
Publisher site
See Article on Publisher Site

Abstract

Keywords Indole-2-carboxamide  Antibacterial  Antifungal  SAR study Introduction For the normal growth of animals and microbes, the interactions between them are intimate and vital, yet they also have darker side, since microbes trigger a broad range of human diseases. History observes continual battle between human beings and disease-causing microbes. In the field of medicine, invention of and advancements in antibiotics are among the most astonishing achievements of the last century. However, these advances in medical care are threatened by a natural phenomenon known as antimicrobial resistance [1–4]. Antimicrobial resistance is the result of inadequate, empirical, self-medicated, improper, and overuse of antibiotics, a gift of the medical field, for the treatment of diseases. Antibiotic resistance is not new; it is ancient [5]. Infection-causing Gram-negative bacteria, about 50 % of the multidrug- resistant bacteria [6], including Escherichia coli, Pseudomonas aeruginosa,and Acinetobacter baumannii [7], have become a serious threat in hospitals and community clinics [8]. Increasing multidrug-resistant (MDR) infections caused by Gram-negative bacteria are more difficult to treat, since they increase mortality, morbidity [9, 10], and health care cost. In spite of a large number of antibiotics and chemotherapeutics available for medical use, the emergence of multidrug bacterial resistance to

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Aug 19, 2016

References

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