Keywords Indole-2-carboxamide Antibacterial Antifungal SAR study Introduction For the normal growth of animals and microbes, the interactions between them are intimate and vital, yet they also have darker side, since microbes trigger a broad range of human diseases. History observes continual battle between human beings and disease-causing microbes. In the ﬁeld of medicine, invention of and advancements in antibiotics are among the most astonishing achievements of the last century. However, these advances in medical care are threatened by a natural phenomenon known as antimicrobial resistance [1–4]. Antimicrobial resistance is the result of inadequate, empirical, self-medicated, improper, and overuse of antibiotics, a gift of the medical ﬁeld, for the treatment of diseases. Antibiotic resistance is not new; it is ancient . Infection-causing Gram-negative bacteria, about 50 % of the multidrug- resistant bacteria , including Escherichia coli, Pseudomonas aeruginosa,and Acinetobacter baumannii , have become a serious threat in hospitals and community clinics . Increasing multidrug-resistant (MDR) infections caused by Gram-negative bacteria are more difﬁcult to treat, since they increase mortality, morbidity [9, 10], and health care cost. In spite of a large number of antibiotics and chemotherapeutics available for medical use, the emergence of multidrug bacterial resistance to
Research on Chemical Intermediates – Springer Journals
Published: Aug 19, 2016
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