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Shashi Pandey, Shikha Chauhan, Rahul Shivahare, Abhisheak Sharma, S. Jaiswal, Suman Gupta, J. Lal, P. Chauhan (2016)
Identification of a diverse indole-2-carboxamides as a potent antileishmanial chemotypes.European journal of medicinal chemistry, 110
I. Raad, H. Hanna, R. Hachem, T. Dvorak, R. Arbuckle, Gassan Chaiban, L. Rice (2004)
Clinical-Use-Associated Decrease in Susceptibility of Vancomycin-Resistant Enterococcus faecium to Linezolid: a Comparison with Quinupristin-DalfopristinAntimicrobial Agents and Chemotherapy, 48
J. Jackman, C. Raetz, C. Fierke (2001)
Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site.Biochemistry, 40 2
D. Fidler (1998)
Legal issues associated with antimicrobial drug resistance.Emerging Infectious Diseases, 4
Jeff Pootoolal, J. Neu, Gerard Wright (2003)
Glycopeptide antibiotic resistance.Annual review of pharmacology and toxicology, 42
Thuy-Ai Nguyen, N. German, A. Decker, Jun-Xu Li, J. Wiley, B. Thomas, T. Kenakin, Yanan Zhang (2015)
Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators.Bioorganic & medicinal chemistry, 23 9
J. Jackman, C. Fierke, L. Tumey, M. Pirrung, T. Uchiyama, S. Tahir, O. Hindsgaul, C. Raetz (2000)
Antibacterial Agents That Target Lipid A Biosynthesis in Gram-negative BacteriaThe Journal of Biological Chemistry, 275
K. Young, L. Silver, D. Bramhill, P. Cameron, S. Eveland, C. Raetz, S. Hyland, M. Anderson (1995)
The envA Permeability/Cell Division Gene of Escherichia coli Encodes the Second Enzyme of Lipid A BiosynthesisThe Journal of Biological Chemistry, 270
H. Boucher, G. Talbot, J. Bradley, J. Edwards, D. Gilbert, L. Rice, M. Scheld, B. Spellberg, J. Bartlett (2009)
Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 48 1
Erin Cawston, M. Connor, V. Marzo, R. Silvestri, M. Glass (2015)
Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid Receptors.Journal of medicinal chemistry, 58 15
Pooja, P. Prasher, Palwinder Singh, Kalpana Pawar, K. Vikramdeo, N. Mondal, S. Komath (2014)
Synthesis of amino acid appended indoles: appreciable anti-fungal activity and inhibition of ergosterol biosynthesis as their probable mode of action.European journal of medicinal chemistry, 80
P. Cowley, James Baker, K. Buchanan, I. Carlyle, J. Clark, Thomas Clarkson, M. Deehan, Darren Edwards, Yasuko Kiyoi, Iain Martin, D. Osbourn, G. Walker, N. Ward, G. Wishart (2011)
Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists.Bioorganic & medicinal chemistry letters, 21 7
Ming-Zhi Zhang, Qiong Chen, Guangfu Yang (2014)
A review on recent developments of indole-containing antiviral agentsEuropean Journal of Medicinal Chemistry, 89
C. Pedersen (2004)
Unleashing the 'love' hormoneNature Medicine, 10
Yali Song, Fan Wu, Chaochao Zhang, Guo-chao Liang, Guan Zhou, Jiaojiao Yu (2015)
Ionic liquid catalyzed synthesis of 2-(indole-3-yl)-thiochroman-4-ones and their novel antifungal activities.Bioorganic & medicinal chemistry letters, 25 2
R. Dolle (2001)
Comprehensive survey of combinatorial library synthesis: 2000.Journal of combinatorial chemistry, 3 6
Daniel Diekema, B. BootsMiller, T. Vaughn, R. Woolson, Jon Yankey, E. Ernst, S. Flach, Marcia Ward, C. Franciscus, M. Pfaller, B. Doebbeling (2004)
Antimicrobial resistance trends and outbreak frequency in United States hospitals.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 38 1
(1000)
Bioorg
D. Hoover, S. Lefkowitz-Snow, J. Burgess-Henry, W. Martin, S. Armento, I. Stock, R. McPherson, P. Genereux, E. Gibbs, J. Treadway (1998)
Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.Journal of medicinal chemistry, 41 16
Kevin Chen, B. Vibulbhan, Weiying Yang, M. Sannigrahi, F. Velázquez, T. Chan, S. Venkatraman, G. Anilkumar, Qingbei Zeng, F. Bennet, Yueheng Jiang, C. Lesburg, J. Duca, P. Pinto, Stephen Gavalas, Yuhua Huang, Wanli Wu, O. Selyutin, S. Agrawal, B. Feld, Hsueh‐Cheng Huang, Cheng Li, K. Cheng, N. Shih, J. Kozlowski, S. Rosenblum, F. Njoroge (2012)
Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.Journal of medicinal chemistry, 55 2
L. Rice (2007)
Emerging issues in the management of infections caused by multidrug-resistant gram-negative bacteria.Cleveland Clinic journal of medicine, 74 Suppl 4
M. Brands, J. Ergüden, Kentaro Hashimoto, D. Heimbach, Christian Schröder, S. Siegel, J. Stasch, S. Weigand (2005)
Novel, selective indole-based ECE inhibitors: lead optimization via solid-phase and classical synthesis.Bioorganic & medicinal chemistry letters, 15 19
J. Stec, Oluseye Onajole, S. Lun, Haidan Guo, Benjamin Merenbloom, G. Vistoli, W. Bishai, A. Kozikowski (2016)
Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection.Journal of medicinal chemistry, 59 13
Marc-Oliver Wright (2005)
Multi-resistant gram-negative organisms in Maryland: a statewide survey of resistant Acinetobacter baumannii.American journal of infection control, 33 7
K. Onda, R. Shiraki, Takashi Ogiyama, K. Yokoyama, K. Momose, N. Katayama, M. Orita, Tomohiko Yamaguchi, Masako Furutani, N. Hamada, M. Takeuchi, M. Okada, M. Ohta, S. Tsukamoto (2008)
Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors.Bioorganic & medicinal chemistry, 16 23
Vanessa D’Costa, Christine King, L. Kalan, M. Morar, Wilson Sung, Carsten Schwarz, D. Froese, G. Zazula, F. Calmels, R. Debruyne, G. Golding, H. Poinar, Gerard Wright (2011)
Antibiotic resistance is ancientNature, 477
N. Kaushik, Neha Kaushik, P. Attri, Naresh Kumar, Chung Kim, A. Verma, E. Choi (2013)
Biomedical Importance of IndolesMolecules, 18
G. Morse, R. Reichman, M. Fischl, M. Para, J. Leedom, W. Powderly, L. Demeter, L. Resnick, Y. Bassiakos, J. Timpone, S. Cox, D. Batts (2000)
Concentration-targeted phase I trials of atevirdine mesylate in patients with HIV infection: dosage requirements and pharmacokinetic studies. The ACTG 187 and 199 study teams.Antiviral research, 45 1
R. Kondreddi, Jan Jiricek, Srinivasa Rao, Suresh Lakshminarayana, Luis Camacho, R. Rao, M. Hervé, P. Bifani, N. Ma, K. Kuhen, A. Goh, A. Chatterjee, T. Dick, T. Diagana, U. Manjunatha, Paul Smith (2013)
Design, synthesis, and biological evaluation of indole-2-carboxamides: a promising class of antituberculosis agents.Journal of medicinal chemistry, 56 21
Chen Meng-Hsin, M. Steiner, S. Laszlo, A. Patchett, Mattias Anderson, S. Hyland, H. Onishi, Lynn Silyer, C. Raetz (1999)
Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.Bioorganic & medicinal chemistry letters, 9 3
M. El-Sayed, S. Suzen, N. Altanlar, K. Ohlsen, A. Hilgeroth (2016)
Discovery of bisindolyl-substituted cycloalkane-anellated indoles as novel class of antibacterial agents against S. aureus and MRSA.Bioorganic & medicinal chemistry letters, 26 1
M. Ferraro (2000)
Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically : approved standard
E. Stout, B. Morinaka, Yong-Gang Wang, D. Romo, Tadeusz Molinski (2012)
De novo synthesis of benzosceptrin C and nagelamide H from 7-15N-oroidin: implications for pyrrole-aminoimidazole alkaloid biosynthesis.Journal of natural products, 75 4
A. Macchiarulo, G. Costantino, Daniele Fringuelli, A. Vecchiarelli, F. Schiaffella, R. Fringuelli (2002)
1,4-Benzothiazine and 1,4-benzoxazine imidazole derivatives with antifungal activity: a docking study.Bioorganic & medicinal chemistry, 10 11
D. Leung, G. Abbenante, D. Fairlie (2000)
Protease inhibitors: current status and future prospects.Journal of medicinal chemistry, 43 3
Valeria Famiglini, G. Regina, Antonio Coluccia, Sveva Pelliccia, A. Brancale, G. Maga, E. Crespan, R. Badia, E. Riveira-Muñoz, J. Esté, R. Ferretti, R. Cirilli, C. Zamperini, M. Botta, D. Schols, V. Limongelli, Bruno Agostino, E. Novellino, R. Silvestri (2014)
Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.Journal of medicinal chemistry, 57 23
F. Goldstein (2007)
Combating resistance in a challenging, changing environment.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 13 Suppl 2
A. Scozzafava, C. Supuran (2000)
Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.Journal of medicinal chemistry, 43 20
Fernando Alves, E. Barreiro, C. Fraga (2009)
From nature to drug discovery: the indole scaffold as a 'privileged structure'.Mini reviews in medicinal chemistry, 9 7
F. Piscitelli, A. Ligresti, G. Regina, Antonio Coluccia, Ludovica Morera, M. Allarà, E. Novellino, V. Marzo, R. Silvestri (2012)
Indole-2-carboxamides as allosteric modulators of the cannabinoid CB₁ receptor.Journal of medicinal chemistry, 55 11
Laura Cleghorn, S. Albrecht, L. Stojanovski, Frederick Simeons, S. Norval, Robert Kime, I. Collie, M. Rycker, Lorna Campbell, I. Hallyburton, J. Frearson, P. Wyatt, K. Read, I. Gilbert (2015)
Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma bruceiJournal of Medicinal Chemistry, 58
T. Kline, N. Andersen, E. Harwood, J. Bowman, André Malanda, Stephanie Endsley, A. Erwin, M. Doyle, S. Fong, A. Harris, B. Mendelsohn, K. Mdluli, C. Raetz, C. Stover, P. Witte, A. Yabannavar, Shuguang Zhu (2002)
Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC.Journal of medicinal chemistry, 45 14
Matthew Welsch, S. Snyder, B. Stockwell (2010)
Privileged scaffolds for library design and drug discovery.Current opinion in chemical biology, 14 3
S. Levy, B. Marshall (2004)
Antibacterial resistance worldwide: causes, challenges and responsesNature Medicine, 10 Suppl 1
C. Kuehm-Caubère, P. Caubére, B. Jamart-Grégoire, A. Nègre-Salvayre, D. Bonnefont-Rousselot, J. Bizot-Espiard, B. Pfeiffer, D. Caignard, B. Guardiola‐Lemaître, P. Renard (1997)
Novel indole-2-carboxamide and cycloalkeno[1,2-b]indole derivatives. Structure-activity relationships for high inhibition of human LDL peroxidation.Journal of medicinal chemistry, 40 8
F. Ban, E. Leblanc, Huifang Li, R. Munuganti, Kate Frewin, P. Rennie, A. Cherkasov (2014)
Discovery of 1H-indole-2-carboxamides as novel inhibitors of the androgen receptor binding function 3 (BF3).Journal of medicinal chemistry, 57 15
M. Mahmoud, Hamed Ali, K. Ahn, Aparna Damaraju, Sushma Samala, V. Pulipati, S. Kolluru, D. Kendall, D. Lu (2013)
Structure-activity relationship study of indole-2-carboxamides identifies a potent allosteric modulator for the cannabinoid receptor 1 (CB1).Journal of medicinal chemistry, 56 20
Zhiguo Liu, Longguang Tang, Heping Zhu, Tingting Xu, Chenyu Qiu, Suqing Zheng, Yugui Gu, Jian-peng Feng, Yali Zhang, G. Liang (2016)
Design, Synthesis, and Structure-Activity Relationship Study of Novel Indole-2-carboxamide Derivatives as Anti-inflammatory Agents for the Treatment of Sepsis.Journal of medicinal chemistry, 59 10
Changjiang Qiao, Hamed Ali, K. Ahn, S. Kolluru, D. Kendall, D. Lu (2016)
Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor.European journal of medicinal chemistry, 121
G. Regina, Antonio Coluccia, A. Brancale, F. Piscitelli, V. Gatti, G. Maga, A. Samuele, C. Pannecouque, D. Schols, J. Balzarini, E. Novellino, R. Silvestri (2011)
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.Journal of medicinal chemistry, 54 6
M. Leeb (2004)
A shot in the armNature, 431
K. Sweidan, D. Sabbah, S. Bardaweel, Khadeja Dush, G. Sheikha, Mohammad Mubarak (2016)
Computer-aided design, synthesis, and biological evaluation of new indole-2-carboxamide derivatives as PI3Kα/EGFR inhibitors.Bioorganic & medicinal chemistry letters, 26 11
Kevin Chen, S. Venkatraman, G. Anilkumar, Qingbei Zeng, C. Lesburg, B. Vibulbhan, F. Velázquez, T. Chan, F. Bennet, Yueheng Jiang, P. Pinto, Yuhua Huang, O. Selyutin, S. Agrawal, Hsueh‐Cheng Huang, Cheng Li, K. Cheng, N. Shih, J. Kozlowski, S. Rosenblum, F. Njoroge (2014)
Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate.ACS medicinal chemistry letters, 5 3
G. Shattat, T. Al-qirim, G. Sheikha, Y. Al-Hiari, K. Sweidan, Rania Al-Qirim, Suhair Hikmat, Lama Hamadneh, Sameer Al-kouz (2013)
The Pharmacological effects of novel 5-fluoro-N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1H-indole-2-carboxamide derivatives on plasma lipid profile of Triton-WR-1339-induced Wistar ratsJournal of Enzyme Inhibition and Medicinal Chemistry, 28
Keywords Indole-2-carboxamide Antibacterial Antifungal SAR study Introduction For the normal growth of animals and microbes, the interactions between them are intimate and vital, yet they also have darker side, since microbes trigger a broad range of human diseases. History observes continual battle between human beings and disease-causing microbes. In the field of medicine, invention of and advancements in antibiotics are among the most astonishing achievements of the last century. However, these advances in medical care are threatened by a natural phenomenon known as antimicrobial resistance [1–4]. Antimicrobial resistance is the result of inadequate, empirical, self-medicated, improper, and overuse of antibiotics, a gift of the medical field, for the treatment of diseases. Antibiotic resistance is not new; it is ancient [5]. Infection-causing Gram-negative bacteria, about 50 % of the multidrug- resistant bacteria [6], including Escherichia coli, Pseudomonas aeruginosa,and Acinetobacter baumannii [7], have become a serious threat in hospitals and community clinics [8]. Increasing multidrug-resistant (MDR) infections caused by Gram-negative bacteria are more difficult to treat, since they increase mortality, morbidity [9, 10], and health care cost. In spite of a large number of antibiotics and chemotherapeutics available for medical use, the emergence of multidrug bacterial resistance to
Research on Chemical Intermediates – Springer Journals
Published: Aug 19, 2016
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