Keywords 1,2,3-Triazole Pyrazoline Hybrids Solvent-free Antibacterial activity Structure–activity relationship Introduction A statistical report of the World Health Organization (WHO) reveals that antimicrobial resistance has become a major threat and challenge to human society. Some of the commonly encountered human pathogens, such as Staphylococcus aureus, Klebsiella pneumonia, and Escherichia coli, cause diseases such as sepsis, meningitis, necrotizing fasciitis, pneumonia [1, 2], nosocomial pneumonia [3, 4], cystic ﬁbrosis, acute leukemia , etc. Many antibiotics belonging to the b-lactam, aminoglycoside, semisynthetic aminoglycoside, etc. classes have been used as drugs to control infections caused by these pathogens. However, these pathogens have developed resistance to such drugs by evolving drug-resistant strains. In particular, Staphylococcus aureus has evolved various drug-resistant strains, such as penicillin- resistant Staphylococcus aureus (PRSA), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Staphylococcus aureus (VRSA). Hence, synthesis of new classes of antibacterial drugs to control such pathogens is urgently needed in the present scenario. Pyrazoline is one of the nitrogen-containing ﬁve-membered heterocycles, exhibiting diverse biological activities such as antimicrobial , antiinﬂammatory , analgesic , anticancer , anticonvulsant , anthelmintic , and antioxidant  actions. On the other hand, investigations on the bioactivity of compounds containing the 1,2,3-triazole scaffold
Research on Chemical Intermediates – Springer Journals
Published: Oct 26, 2016
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