Design, synthesis, and antibacterial studies of potent pyrazolinyltriazoles

Design, synthesis, and antibacterial studies of potent pyrazolinyltriazoles Keywords 1,2,3-Triazole  Pyrazoline  Hybrids  Solvent-free  Antibacterial activity  Structure–activity relationship Introduction A statistical report of the World Health Organization (WHO) reveals that antimicrobial resistance has become a major threat and challenge to human society. Some of the commonly encountered human pathogens, such as Staphylococcus aureus, Klebsiella pneumonia, and Escherichia coli, cause diseases such as sepsis, meningitis, necrotizing fasciitis, pneumonia [1, 2], nosocomial pneumonia [3, 4], cystic fibrosis, acute leukemia [5], etc. Many antibiotics belonging to the b-lactam, aminoglycoside, semisynthetic aminoglycoside, etc. classes have been used as drugs to control infections caused by these pathogens. However, these pathogens have developed resistance to such drugs by evolving drug-resistant strains. In particular, Staphylococcus aureus has evolved various drug-resistant strains, such as penicillin- resistant Staphylococcus aureus (PRSA), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Staphylococcus aureus (VRSA). Hence, synthesis of new classes of antibacterial drugs to control such pathogens is urgently needed in the present scenario. Pyrazoline is one of the nitrogen-containing five-membered heterocycles, exhibiting diverse biological activities such as antimicrobial [6], antiinflammatory [7], analgesic [7], anticancer [8], anticonvulsant [9], anthelmintic [10], and antioxidant [11] actions. On the other hand, investigations on the bioactivity of compounds containing the 1,2,3-triazole scaffold http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals
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Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2774-6
Publisher site
See Article on Publisher Site

Abstract

Keywords 1,2,3-Triazole  Pyrazoline  Hybrids  Solvent-free  Antibacterial activity  Structure–activity relationship Introduction A statistical report of the World Health Organization (WHO) reveals that antimicrobial resistance has become a major threat and challenge to human society. Some of the commonly encountered human pathogens, such as Staphylococcus aureus, Klebsiella pneumonia, and Escherichia coli, cause diseases such as sepsis, meningitis, necrotizing fasciitis, pneumonia [1, 2], nosocomial pneumonia [3, 4], cystic fibrosis, acute leukemia [5], etc. Many antibiotics belonging to the b-lactam, aminoglycoside, semisynthetic aminoglycoside, etc. classes have been used as drugs to control infections caused by these pathogens. However, these pathogens have developed resistance to such drugs by evolving drug-resistant strains. In particular, Staphylococcus aureus has evolved various drug-resistant strains, such as penicillin- resistant Staphylococcus aureus (PRSA), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Staphylococcus aureus (VRSA). Hence, synthesis of new classes of antibacterial drugs to control such pathogens is urgently needed in the present scenario. Pyrazoline is one of the nitrogen-containing five-membered heterocycles, exhibiting diverse biological activities such as antimicrobial [6], antiinflammatory [7], analgesic [7], anticancer [8], anticonvulsant [9], anthelmintic [10], and antioxidant [11] actions. On the other hand, investigations on the bioactivity of compounds containing the 1,2,3-triazole scaffold

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Oct 26, 2016

References

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