Design and evaluation of artificial cornea with core–skirt design using polyhydroxyethyl methacrylate and graphite

Design and evaluation of artificial cornea with core–skirt design using polyhydroxyethyl... Int Ophthalmol (2018) 38:1225–1233 https://doi.org/10.1007/s10792-017-0586-3 ORIGINAL PAPER Design and evaluation of artificial cornea with core–skirt design using polyhydroxyethyl methacrylate and graphite Mukty Sinha Tanvi Gupte Received: 23 September 2016 / Accepted: 5 June 2017 / Published online: 10 June 2017 Springer Science+Business Media B.V. 2017 Abstract behaviour, mechanical strength, water vapour perme- Purpose Artificial cornea is the effective treatment ability, degradation profile and cell adhesion. option for corneal blindness. One of the challenges Results The polymerization of HEMA was con- with the artificial cornea is limited, or no tissue firmed by thin layer chromatography and FTIR. Water integration necessitates reimplantation due to necrosis content of the polymeric film was optimized at 50% or corneal melting. We propose here a new formula- where maximum transparency with required refractive tion approach for core–skirt incorporating graphite in index of 1.4 was obtained. The concentration of salt the outer skirt region to improve cell adhesion. vital for the essential porosity was also optimized Methods Hydroxyethyl methacrylate (HEMA) and using optical microscopy and scanning electron ethylene glycol dimethacrylate were procured from microscopy. Other properties, namely mechanical Sigma-Aldrich. Polyhydroxyethyl methacrylate strength, water vapour transmission rate and degrada- (PHEMA) was synthesized by free radical polymer- tion http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Ophthalmology Springer Journals

Design and evaluation of artificial cornea with core–skirt design using polyhydroxyethyl methacrylate and graphite

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Science+Business Media B.V.
Subject
Medicine & Public Health; Ophthalmology
ISSN
0165-5701
eISSN
1573-2630
D.O.I.
10.1007/s10792-017-0586-3
Publisher site
See Article on Publisher Site

Abstract

Int Ophthalmol (2018) 38:1225–1233 https://doi.org/10.1007/s10792-017-0586-3 ORIGINAL PAPER Design and evaluation of artificial cornea with core–skirt design using polyhydroxyethyl methacrylate and graphite Mukty Sinha Tanvi Gupte Received: 23 September 2016 / Accepted: 5 June 2017 / Published online: 10 June 2017 Springer Science+Business Media B.V. 2017 Abstract behaviour, mechanical strength, water vapour perme- Purpose Artificial cornea is the effective treatment ability, degradation profile and cell adhesion. option for corneal blindness. One of the challenges Results The polymerization of HEMA was con- with the artificial cornea is limited, or no tissue firmed by thin layer chromatography and FTIR. Water integration necessitates reimplantation due to necrosis content of the polymeric film was optimized at 50% or corneal melting. We propose here a new formula- where maximum transparency with required refractive tion approach for core–skirt incorporating graphite in index of 1.4 was obtained. The concentration of salt the outer skirt region to improve cell adhesion. vital for the essential porosity was also optimized Methods Hydroxyethyl methacrylate (HEMA) and using optical microscopy and scanning electron ethylene glycol dimethacrylate were procured from microscopy. Other properties, namely mechanical Sigma-Aldrich. Polyhydroxyethyl methacrylate strength, water vapour transmission rate and degrada- (PHEMA) was synthesized by free radical polymer- tion

Journal

International OphthalmologySpringer Journals

Published: Jun 10, 2017

References

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