Int Ophthalmol (2018) 38:1225–1233 https://doi.org/10.1007/s10792-017-0586-3 ORIGINAL PAPER Design and evaluation of artiﬁcial cornea with core–skirt design using polyhydroxyethyl methacrylate and graphite Mukty Sinha Tanvi Gupte Received: 23 September 2016 / Accepted: 5 June 2017 / Published online: 10 June 2017 Springer Science+Business Media B.V. 2017 Abstract behaviour, mechanical strength, water vapour perme- Purpose Artiﬁcial cornea is the effective treatment ability, degradation proﬁle and cell adhesion. option for corneal blindness. One of the challenges Results The polymerization of HEMA was con- with the artiﬁcial cornea is limited, or no tissue ﬁrmed by thin layer chromatography and FTIR. Water integration necessitates reimplantation due to necrosis content of the polymeric ﬁlm was optimized at 50% or corneal melting. We propose here a new formula- where maximum transparency with required refractive tion approach for core–skirt incorporating graphite in index of 1.4 was obtained. The concentration of salt the outer skirt region to improve cell adhesion. vital for the essential porosity was also optimized Methods Hydroxyethyl methacrylate (HEMA) and using optical microscopy and scanning electron ethylene glycol dimethacrylate were procured from microscopy. Other properties, namely mechanical Sigma-Aldrich. Polyhydroxyethyl methacrylate strength, water vapour transmission rate and degrada- (PHEMA) was synthesized by free radical polymer- tion
International Ophthalmology – Springer Journals
Published: Jun 10, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera