Qual Life Res (2017) 26:2459–2469 DOI 10.1007/s11136-017-1595-4 Depression severity and concentration difﬁculties are independently associated with HRQOL in patients with unipolar depressive disorders 1 2 3 4 5 • • • • • A. Fattori L. Neri A. Bellomo M. Vaggi C. Mencacci the ILDE Study Group Accepted: 9 May 2017 / Published online: 13 May 2017 Springer International Publishing Switzerland 2017 Abstract SF-12 domains. Additionally, we observed a strong asso- Purpose Cognitive impairment is a core feature of major ciation between concentration difﬁculties and all HRQOL depressive disorder (MDD), and dysfunctions in this area outcomes independent of other symptoms of depression strongly contribute to MDD-associated disability. Whether and robust to adjustment for possible confounders. cognitive impairment has an independent clinical course Conclusions Our data corroborate previous ﬁndings sug- and a unique impact on HRQOL is still debated. We sought gesting that cognitive impairment is a feature of unipolar to characterize the relationship between depression severity depressive disorders partially independent of the severity and HRQOL, evaluating the burden of concentration dif- of other symptoms, and may represent a speciﬁc target of ﬁculties on HRQOL. therapy with a strong impact on patients’ functioning and Methods Six hundred ninety-two patients with
Quality of Life Research – Springer Journals
Published: May 13, 2017
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