Aesth Plast Surg (2018) 42:1394–1398 https://doi.org/10.1007/s00266-018-1164-4 ORIGINAL ARTICLE BASIC SCIENCE/EXPERIMENTAL Deoxycholic Acid and the Marginal Mandibular Nerve: A Cadaver Study 1 1 2 3 • • • • Alexander D. Blandford Waseem Ansari Jason M. Young Bruce Maley 4 1 1 • • Thomas P. Plesec Catherine J. Hwang Julian D. Perry Received: 4 March 2018 / Accepted: 22 May 2018 / Published online: 4 June 2018 Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2018 Abstract Transmission electron microscopy of submental fat Background One of the rare but serious complications exposed to deoxycholic acid revealed disruption of adipo- observed with deoxycholic acid administration is damage cyte cell membrane integrity and loss of cellular organelles to the marginal mandibular nerve. In this study, we eval- when compared to specimens only exposed to saline. uated if deoxycholic acid directly induces histologic Conclusions Deoxycholic acid (10 mg/ml) damages the damage to fresh cadaveric marginal mandibular nerve. marginal mandibular nerve myelin sheath in fresh human Methods A segment of marginal mandibular nerve was cadaver specimens. Direct deoxycholic acid neurotoxicity harvested from 12 hemifaces of 6 fresh cadavers. The nerve may cause marginal mandibular nerve injury
Aesthetic Plastic Surgery – Springer Journals
Published: Jun 4, 2018
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