Deltoid muscle morphometry as an index of impaired skeletal muscularity in neonatal intensive care

Deltoid muscle morphometry as an index of impaired skeletal muscularity in neonatal intensive care We hypothesised that extremely premature infants would have decreased muscle mass at term-corrected age compared to term-born infants and that the degree of reduced muscle mass acquisition would correlate with the duration of invasive mechanical ventilation. The MRI brain scans of infants admitted in the neonatal unit at King’s College Hospital between 1 January 2010 and 1 June 2016 were retrospectively reviewed. The coronal cross-sectional area of the left deltoid muscle (DCSA) was measured in 17 infants born < 28 weeks of gestation and in 20 infants born at term. The prematurely born infants had a median (IQR) gestation age of 25 weeks (24–27) and the term infants 40 weeks (38–41). The duration of invasive mechanical ventilation for the prematurely born infants was 39 days (14–62) and that for the term infants 4 days (2–5), p < 0.001. DCSA was smaller in prematurely born infants (median 189, IQR 176–223 mm2) compared to term-born infants (median 302, IQR 236–389 mm2), p < 0.001. DCSA was related to gestation age (r = 0.545, p = 0.001), weight z-score at MRI (r = 0.658, p < 0.001) and days of invasive mechanical ventilation (r = − 0.583, p < 0.001). In conclusion, extremely premature infants studied at term had a lower muscle mass compared to term-born infants. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pediatrics Springer Journals

Deltoid muscle morphometry as an index of impaired skeletal muscularity in neonatal intensive care

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Pediatrics
ISSN
0340-6199
eISSN
1432-1076
D.O.I.
10.1007/s00431-018-3090-5
Publisher site
See Article on Publisher Site

Abstract

We hypothesised that extremely premature infants would have decreased muscle mass at term-corrected age compared to term-born infants and that the degree of reduced muscle mass acquisition would correlate with the duration of invasive mechanical ventilation. The MRI brain scans of infants admitted in the neonatal unit at King’s College Hospital between 1 January 2010 and 1 June 2016 were retrospectively reviewed. The coronal cross-sectional area of the left deltoid muscle (DCSA) was measured in 17 infants born < 28 weeks of gestation and in 20 infants born at term. The prematurely born infants had a median (IQR) gestation age of 25 weeks (24–27) and the term infants 40 weeks (38–41). The duration of invasive mechanical ventilation for the prematurely born infants was 39 days (14–62) and that for the term infants 4 days (2–5), p < 0.001. DCSA was smaller in prematurely born infants (median 189, IQR 176–223 mm2) compared to term-born infants (median 302, IQR 236–389 mm2), p < 0.001. DCSA was related to gestation age (r = 0.545, p = 0.001), weight z-score at MRI (r = 0.658, p < 0.001) and days of invasive mechanical ventilation (r = − 0.583, p < 0.001). In conclusion, extremely premature infants studied at term had a lower muscle mass compared to term-born infants.

Journal

European Journal of PediatricsSpringer Journals

Published: Jan 19, 2018

References

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