Pharm Res (2018) 35:68 https://doi.org/10.1007/s11095-018-2369-6 RESEARCH PAPER Delivery of Methotrexate and Characterization of Skin Treated by Fabricated PLGA Microneedles and Fractional Ablative Laser 1 1 Hiep X. Nguyen & Ajay K. Banga Received: 29 November 2017 /Accepted: 12 February 2018 # Springer Science+Business Media, LLC, part of Springer Nature 2018 . . KEY WORDS characterization fractional ablative laser ABSTRACT . . Purpose This study investigated in vitro transdermal delivery methotrexate polymeric biodegradable microneedles skin of methotrexate through dermatomed porcine ear and cadav- delivery er human skin treated with poly (D,L-lactide-co-glycolide) ac- id microneedles or fractional ablative laser. Methods PLGA microneedles were fabricated and charac- ABBREVIATIONS terized using scanning electron microscopy and mechanical FTIR Fourier transform infrared spectrophotometer assessment techniques. The integrity of treated skin was eval- MN Microneedles uated by rheometer, transepidermal water loss, and skin elec- MTX Methotrexate trical resistance measurements. Successful skin microporation PBS Phosphate buffered saline was demonstrated by dye binding, histology, pore uniformity, PDMS Polydimethylsiloxane confocal laser microscopy, and DermaScan studies. In vitro PLGA Poly Lactic-co-Glycolic Acid permeation experiment was performed on Franz diffusion PPI Pore permeability index cells to determine drug delivery into and across the skin. RP-HPLC Reversed-phase high performance liquid Results Both
Pharmaceutical Research – Springer Journals
Published: Feb 21, 2018
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