Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Kjems, B. Calnan, A. Frankel, P. Sharp (1992)
Specific binding of a basic peptide from HIV‐1 Rev.The EMBO Journal, 11
L. Venkatesh, G. Chinnadurai (1990)
Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype.Virology, 178 1
Sarah Thomas, M. Oft, H. Jaksche, G. Casari, P. Heger, Marika Dobrovnik, D. Bevec, J. Hauber (1998)
Functional Analysis of the Human Immunodeficiency Virus Type 1 Rev Protein Oligomerization InterfaceJournal of Virology, 72
T. Daly, R. Doten, J. Rusche, M. Auer (1995)
The amino terminal domain of HIV-1 Rev is required for discrimination of the RRE from nonspecific RNA.Journal of molecular biology, 253 2
Barbara Meyer, M. Malim (1994)
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.Genes & development, 8 13
M. Hadzopoulou-Cladaras, B. Felber, C. Cladaras, Angelos, Athanassopoulos, Anthony Tse, G. Pavlakis (1989)
The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env regionJournal of Virology, 63
A. Szilvay, K. Brokstad, R. Kopperud, G. Haukenes, K. Kalland (1995)
Nuclear export of the human immunodeficiency virus type 1 nucleocytoplasmic shuttle protein Rev is mediated by its activation domain and is blocked by transdominant negative mutantsJournal of Virology, 69
H. Bogerd, R. Fridell, S. Madore, B. Cullen (1995)
Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteinsCell, 82
R. Tan, A. Frankel (1994)
Costabilization of peptide and RNA structure in an HIV Rev peptide-RRE complex.Biochemistry, 33 48
D. Fouts, H. True, K. Cengel, D. Celander (1997)
Site-specific phosphorylation of the human immunodeficiency virus type-1 Rev protein accelerates formation of an efficient RNA-binding conformation.Biochemistry, 36 43
M. Zapp, T. Hope, T. Parslow, M. Green (1991)
Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif.Proceedings of the National Academy of Sciences of the United States of America, 88 17
T. Rana, K. Jeang (1999)
Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA.Archives of biochemistry and biophysics, 365 2
C. Fritz, M. Zapp, Michael Green (1995)
A human nucleoporin-like protein that specifically interacts with HIV RevNature, 376
Sunyoung Kim, R. Byrn, J. Groopman, D. Baltimore (1989)
Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expressionJournal of Virology, 63
S. Escaich, C. Kalfoglou, I. Plavec, S. Kaushal, J. Mosca, E. Böhnlein (1995)
RevM10-mediated inhibition of HIV-1 replication in chronically infected T cells.Human gene therapy, 6 5
Jørgen Kjems, Myles Brown, David Chang, P. Sharp (1991)
Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element.Proceedings of the National Academy of Sciences of the United States of America, 88 3
Henrik Olsen, Alan Cochrane, Patrick lon, Carlo Nalin, Craig Rosen (1990)
Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.Genes & development, 4 8
K. Stade, C. Ford, C. Guthrie, K. Weis (1997)
Exportin 1 (Crm1p) Is an Essential Nuclear Export FactorCell, 90
S. Madore, L. Tiley, M. Malim, Bryan Cullen (1994)
Sequence requirements for Rev multimerization in vivo.Virology, 202 1
E. Bohnlein, J. Berger, J. Hauber (1991)
Functional mapping of the human immunodeficiency virus type 1 Rev RNA binding domain: new insights into the domain structure of Rev and RexJournal of Virology, 65
R. Tan, L. Chen, J. Buettner, D. Hudson, A. Frankel (1993)
RNA recognition by an isolated alpha helix.Cell, 73 5
N. Richard, S. Iacampo, A. Cochrane (1994)
HIV-1 Rev is capable of shuttling between the nucleus and cytoplasm.Virology, 204 1
D. McDonald, T. Hope, T. Parslow (1992)
Posttranscriptional regulation by the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex proteins through a heterologous RNA binding siteJournal of Virology, 66
C. Rosen, E. Terwilliger, A. Dayton, J. Sodroski, W. Haseltine (1988)
Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus.Proceedings of the National Academy of Sciences of the United States of America, 85 7
K. Kalland, A. Szilvay, K. Brokstad, W. Saetrevik, G. Haukenes (1994)
The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments.Molecular and cellular biology, 14 11
S. Heaphy, J. Finch, M. Gait, J. Karn, Mohinder Singh (1991)
Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.Proceedings of the National Academy of Sciences of the United States of America, 88
F. Stutz, M. Neville, M. Rosbash (1995)
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeastCell, 82
B. Wolff, G. Cohen, J. Hauber, D. Meshcheryakova, C. Rabeck (1995)
Nucleocytoplasmic transport of the Rev protein of human immunodeficiency virus type 1 is dependent on the activation domain of the protein.Experimental cell research, 217 1
M. Feinberg, R. Jarrett, A. Aldovini, R. Gallo, F. Wong-Staal (1986)
HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNACell, 46
M. Malim, D. McCarn, L. Tiley, Bryan Cullen (1991)
Mutational definition of the human immunodeficiency virus type 1 Rev activation domainJournal of Virology, 65
D. Ryk, S. Venkatesan (1999)
Real-time Kinetics of HIV-1 Rev-Rev Response Element InteractionsThe Journal of Biological Chemistry, 274
T. Hope, B. Bond, D. McDonald, N. Klein, T. Parslow (1991)
Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motifJournal of Virology, 65
S. Kubota, Rika Furuta, Masatoshi Maki, Masakazu Hatanaka (1992)
Inhibition of human immunodeficiency virus type 1 Rev function by a Rev mutant which interferes with nuclear/nucleolar localization of RevJournal of Virology, 66
U. Fischer, J. Huber, W. Boelens, Lain Mattajt, R. Lührmann (1995)
The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsCell, 82
N. Ahmad, R. Maitra, S. Venkatesan (1989)
Rev-induced modulation of Nef protein underlies temporal regulation of human immunodeficiency virus replication.Proceedings of the National Academy of Sciences of the United States of America, 86 16
M. Malim, W. Freimuth, J. Liu, T. Boyle, H. Lyerly, B. Cullen, G. Nabel (1992)
Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replicationThe Journal of Experimental Medicine, 176
Brion Mermer, B. Felber, Mel Campbell, George Pavlakis (1990)
Identification of trans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells.Nucleic acids research, 18 8
M. Fornerod, M. Ohno, Minoru Yoshida, I. Mattaj (1997)
CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export SignalsCell, 90
S. Holland, N. Ahmad, R. Maitra, P. Wingfield, S. Venkatesan (1992)
Human Immunodeficiency Virus Rev Protein Recognizes a Target Sequence in Rev-Responsive Element RNA within the Context of RNA Secondary StructureJournal of Virology, 66
D. Chang, P. Sharp (1989)
Regulation by HIV Rev depends upon recognition of splice sitesCell, 59
S. Kubota, T. Nosaka, B. Cullen, M. Maki, M. Hatanaka (1991)
Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signalsJournal of Virology, 65
J. Gailit (1993)
Restoring free sulfhydryl groups in synthetic peptides.Analytical biochemistry, 214 1
Sundararajan Venkatesan, S. Gerstberger, H. Park, Steven Holland, Yong-Suk Nam (1992)
Human immunodeficiency virus type 1 Rev activation can be achieved without Rev-responsive element RNA if Rev is directed to the target as a Rev/MS2 fusion protein which tethers the MS2 operator RNAJournal of Virology, 66
Michael Ruhl, M. Himmelspach, G. Bahr, F. Hammerschmid, H. Jaksche, B. Wolff, H. Aschauer, G. Farrington, H. Probst, D. Bevec, J. Hauber (1993)
Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans- activationThe Journal of Cell Biology, 123
S. Heaphy, C. Dingwall, I. Ernberg, M. Gait, S. Green, J. Kern, A. Lowe, Mohinder Singh, M. Skinner (1990)
HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element regionCell, 60
M. Malim, J. Hauber, S. Le, J. Maizel, B. Cullen (1989)
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNANature, 338
M. Malim, L. Tiley, D. McCarn, J. Rusche, J. Hauber, B. Cullen (1990)
HIV-1 structural gene expression requires binding of the rev trans-activator to its RNA target sequenceCell, 60
M. Zapp, Michael Green (1989)
Sequence-specific RNA binding by the HIV-1 Rev proteinNature, 342
M. Malim, B. Cullen (1991)
HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latencyCell, 65
D. Bevec, Marika Dobrovnik, J. Hauber, E. Böhnlein (1992)
Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator.Proceedings of the National Academy of Sciences of the United States of America, 89
J. Battiste, Hongyuan Mao, N. Rao, R. Tan, D. Muhandiram, L. Kay, A. Frankel, J. Williamson (1996)
α Helix-RNA Major Groove Recognition in an HIV-1 Rev Peptide-RRE RNA ComplexScience, 273
Heesung Park, M. Davies, J. Langland, H-W Chang, Y. Nam, J. Tartaglia, E. Paoletti, B. Jacobs, R. Kaufman, S. Venkatesan (1994)
TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.Proceedings of the National Academy of Sciences of the United States of America, 91 11
T. Hope, N. Klein, M. Elder, T. Parslow (1992)
trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexesJournal of Virology, 66
I. Weichselbraun, G. Farrington, J. Rusche, Ernst, Bohnlein, Joachim HAUBERl (1992)
Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchangeJournal of Virology, 66
B. Ossareh‐Nazari, F. Bachelerie, C. Dargemont (1997)
Evidence for a role of CRM1 in signal-mediated nuclear protein export.Science, 278 5335
R. Tan, Lily Chen, J. Buettner, D. Hudson, A. Frankel (1993)
RNA recognition by an isolated α helixCell, 73
J. Kjems, A. Frankel, P. Sharp (1991)
Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 RevCell, 67
P. Wingfield, S. Stahl, M. Payton, S. Venkatesan, M. Misra, A. Steven (1991)
HIV-1 Rev expressed in recombinant Escherichia coli: purification, polymerization, and conformational properties.Biochemistry, 30 30
A. Cochrane, A. Perkins, C. Rosen (1990)
Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to functionJournal of Virology, 64
J. Battiste, R. Tan, A. Frankel, J. Williamson (1994)
Binding of an HIV Rev peptide to Rev responsive element RNA induces formation of purine-purine base pairs.Biochemistry, 33 10
M. Hammerschmid, D. Palmeri, M. Ruhl, H. Jaksche, I. Weichselbraun, E. Böhnlein, M. Malim, J. Hauber (1994)
Scanning mutagenesis of the arginine-rich region of the human immunodeficiency virus type 1 Rev trans activatorJournal of Virology, 68
T. Hope, Xiaojian Huang, D. McDonald, T. Parslow (1990)
Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif.Proceedings of the National Academy of Sciences of the United States of America, 87
M. Fukuda, Shiro Asano, Takahiro Nakamura, Makoto Adachi, Minoru Yoshida, M. Yanagida, E. Nishida (1997)
CRM1 is responsible for intracellular transport mediated by the nuclear export signalNature, 390
M. Malim, S. Böhnlein, J. Hauber, B. Cullen (1989)
Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev functionCell, 58
T. Daly, K. Cook, G. Gray, T. Maione, J. Rusche (1989)
Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitroNature, 342
The contributions of the near N-terminal residues of Rev protein of HIV were investigated by analyzing N-terminal deletions of Rev in the context of a Rev/MS-C fusion protein that can bind and activate both the Rev responsive element (RRE) and the MS2 phage translational operator RNAs. Rev/MS-C fusion proteins deleted for residues 3–19 of Rev retained trans -activation potential for both RRE and MS2 targets. Coincidentally, peptides spanning residues 17–87 or 22–85 were functionally competent for trans -activation of RRE containing HIV-1 gag mRNA. Deletion of residues 18–24 of Rev in the Rev/MS-C fusion protein abolished the activation potential for both RRE and MS2 targets, although this mutant was competent for specific RNA binding, protein multimerization, and nuclear and nucleolar localization. Four mutants dominantly interfering with Rev activation of RRE were mapped near the N-terminus of Rev; (i) between residues 18 and 24, (ii) 25–34, (iii) 43–50, and (iv) 51–60. Of these, the mutant lacking residues 18–24 was a novel trans -dominant inhibitor of Rev and Rev/MS-C for activation of RRE or MS2 RNA, while the oligomerization domain mutants mapping between residues 25–34 or 51–60 inhibited the activation of RRE rather than MS2 RNA.
Archives of Virology – Springer Journals
Published: Dec 1, 2000
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.