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References (19)
-
E. Nam, Changhee Lee (2009)
Contribution of the porcine aminopeptidase N (CD13) receptor density to porcine epidemic diarrhea virus infectionVeterinary Microbiology, 144
-
P. Högger, U. Erpenstein, P. Rohdewald, C. Sorg (1998)
Biochemical Characterization of a Glucocorticoid-Induced Membrane Protein (RM3/1) in Human Monocytes and Its Application as Model System for Ranking Glucocorticoid PotencyPharmaceutical Research, 15
-
P. Das, P. Dinh, I. Ansari, M. Lima, F. Osorio, A. Pattnaik (2009)
The Minor Envelope Glycoproteins GP2a and GP4 of Porcine Reproductive and Respiratory Syndrome Virus Interact with the Receptor CD163Journal of Virology, 84
-
J. Patton, R. Rowland, D. Yoo, Kyeong-Ok Chang (2009)
Modulation of CD163 receptor expression and replication of porcine reproductive and respiratory syndrome virus in porcine macrophages.Virus research, 140 1-2
-
J. Graversen, M. Madsen, S. Moestrup (2002)
CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma.The international journal of biochemistry & cell biology, 34 4
-
E. Albina (1997)
Epidemiology of porcine reproductive and respiratory syndrome (PRRS): an overview.Veterinary microbiology, 55 1-4
-
J. Calvert, D. Slade, S. Shields, R. Jolie, R. Mannan, R. Ankenbauer, S. Welch (2007)
CD163 Expression Confers Susceptibility to Porcine Reproductive and Respiratory Syndrome VirusesJournal of Virology, 81
-
Changhee Lee, D. Yoo (2006)
The small envelope protein of porcine reproductive and respiratory syndrome virus possesses ion channel protein-like propertiesVirology, 355
-
X. Duan, Hans Nauwynck, M. Pensaert (2014)
Effects of origin and state of differentiation and activation of monocytes/macrophages on their susceptibility to porcine reproductive and respiratory syndrome virus (PRRSV)Archives of Virology, 142
-
B. Fabriek, C. Dijkstra, T. Berg (2005)
The macrophage scavenger receptor CD163.Immunobiology, 210 2-4
-
B. Fabriek, R. Bruggen, D. Deng, A. Ligtenberg, K. Nazmi, K. Schornagel, R. Vloet, C. Dijkstra, T. Berg (2009)
The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria.Blood, 113 4
-
M. Kristiansen, J. Graversen, C. Jacobsen, O. Sonne, H. Hoffman, S. Law, S. Moestrup (2001)
Identification of the haemoglobin scavenger receptorNature, 409
-
B. Fabriek, M. Polfliet, R. Vloet, R. Schors, A. Ligtenberg, L. Weaver, Christiaan Geest, K. Matsuno, S. Moestrup, C. Dijkstra, T. Berg (2007)
The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor.Blood, 109 12
-
M Madsen, HJ Møller, MJ Nielsen, C Jacobsen, JH Graversen, T Berg, SK Moestrup (2004)
Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain regionJ Biol Chem, 279
-
Y. Lee, Choi-Kyu Park, E. Nam, Seong-Hee Kim, O. Lee, D. Lee, Changhee Lee (2010)
Generation of a porcine alveolar macrophage cell line for the growth of porcine reproductive and respiratory syndrome virus.Journal of virological methods, 163 2
-
H. Gorp, W. Breedam, J. Doorsselaere, P. Delputte, H. Nauwynck (2009)
Identification of the CD163 Protein Domains Involved in Infection of the Porcine Reproductive and Respiratory Syndrome VirusJournal of Virology, 84
-
M. Madsen, H. Møller, M. Nielsen, C. Jacobsen, J. Graversen, T. Berg, S. Moestrup (2004)
Molecular Characterization of the Haptoglobin·Hemoglobin Receptor CD163Journal of Biological Chemistry, 279
-
E. Neumann, J. Kliebenstein, C. Johnson, J. Mabry, E. Bush, A. Seitzinger, A. Green, J. Zimmerman (2005)
Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States.Journal of the American Veterinary Medical Association, 227 3
-
X. Duan, H. Nauwynck, M. Pensaert (1997)
Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV).Veterinary microbiology, 56 1-2
- Publisher
- Springer Journals
- Copyright
- Copyright © 2010 by Springer-Verlag
- Subject
- Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
- ISSN
- 0304-8608
- eISSN
- 1432-8798
- DOI
- 10.1007/s00705-010-0699-8
- pmid
- 20496088
- Publisher site
- See Article on Publisher Site
Abstract
The macrophage scavenger receptor CD163 is a major determinant for the entry of porcine reproductive and respiratory syndrome virus (PRRSV). The present study was undertaken to assess the functional significance of the intracellular region of CD163 for PRRSV infection. We stably transfected non-susceptible BHK cells with plasmids encoding full-length and cytoplasmic-domain-deleted (tailless) CD163 and evaluated their permissiveness to PRRSV. The experimental data revealed that the tailless CD163 was not only completely sufficient for converting non-target cells to PRRSV susceptibility, but it also notably enhanced virus replication, with significant increases in viral protein synthesis and progeny release. Taken together, our results suggest that the intracellular domain of CD163 may be associated with an important yet-unknown function during PRRSV infection.
Journal
Archives of Virology – Springer Journals
Published: Aug 1, 2010