Mammalian Genome 12, 873–876 (2001). DOI: 10.1007/s00335-001-2027-9 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Deletion of a direct repeat element has no effect on Igf2 and H19 imprinting Michael R. Reed, Arthur D. Riggs, Jeffrey R. Mann Division of Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Rd, Duarte, California 91010-3011, USA Received: 26 April 2001 / Accepted: 21 June 2001 Genomic imprinting is a mammalian epigenetic system that deter- insulator or chromatin boundary function of the ICR (Bell and mines the parent-of-origin dependent or monoallelic expression of Felsenfeld 2000; Hark et al. 2000; Kaffer et al. 2000; Kanduri et al. a subset of genes in mammals (Beechey 2000; Mann et al. 2000). 2000a, 2000b; Szabo ´ et al., 2000) (Fig. 1a). Second, it is located An important component in the somatic regulation of monoallelic between the ICR and the H19 promoter. Thus, it might be crucial expression is DNA methylation. Many imprinted genes contain or for another function of the paternal ICR–inactivation of the pater- are located near differentially methylated regions (DMRs), discrete nal H19 promoter in cis through its methylation and packaging into regions which are methylated on the maternal but
Mammalian Genome – Springer Journals
Published: Apr 20, 2014
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