Deleterious mutations in various Drosophila melanogaster strains carrying meiotic mutation c(3)G

Deleterious mutations in various Drosophila melanogaster strains carrying meiotic mutation c(3)G In the absence of meiotic recombination, deleterious mutations, decreasing the viability, are accumulated and fixed in small Drosophila populations. Study of the viability of hybrid progenies of three laboratory Drosophila melanogaster strains carrying meiotic mutation c(3)G 17 has suggested that the deleterious mutations are negatively synergistic in their interaction. The deleterious mutations localized to the pericentromeric region of chromosome 3 are threefold more efficient as compared with the mutations located in distal regions. Substitution of a new chromosome for the balancer chromosome in a strain with meiotic mutation c(3)G 17 partially restores (by ∼20%) the viability of homozygotes c(3)G 17 /c(3)G 17 over the first 20–30 generations. Further cultivation for 30 generations with the same balancer again decreases the viability to the initial level. An epigenetic nature of deleterious mutations is discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Deleterious mutations in various Drosophila melanogaster strains carrying meiotic mutation c(3)G

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Publisher
SP MAIK Nauka/Interperiodica
Copyright
Copyright © 2008 by MAIK Nauka
Subject
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S102279540809007X
Publisher site
See Article on Publisher Site

Abstract

In the absence of meiotic recombination, deleterious mutations, decreasing the viability, are accumulated and fixed in small Drosophila populations. Study of the viability of hybrid progenies of three laboratory Drosophila melanogaster strains carrying meiotic mutation c(3)G 17 has suggested that the deleterious mutations are negatively synergistic in their interaction. The deleterious mutations localized to the pericentromeric region of chromosome 3 are threefold more efficient as compared with the mutations located in distal regions. Substitution of a new chromosome for the balancer chromosome in a strain with meiotic mutation c(3)G 17 partially restores (by ∼20%) the viability of homozygotes c(3)G 17 /c(3)G 17 over the first 20–30 generations. Further cultivation for 30 generations with the same balancer again decreases the viability to the initial level. An epigenetic nature of deleterious mutations is discussed.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Sep 25, 2008

References

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