Defining the Optimal Target Population for Trials of Polyunsaturated Fatty Acid Supplementation Using the Erythrocyte Omega-3 Index: A Step Towards Personalized Prevention of Cognitive Decline?

Defining the Optimal Target Population for Trials of Polyunsaturated Fatty Acid Supplementation... J Nutr Health Aging. 2018;22(8):982-988 © Serdi and Springer-Verlag International SAS, part of Springer Nature DEFINING THE OPTIMAL TARGET POPULATION FOR TRIALS OF POLYUNSATURATED FATTY ACID SUPPLEMENTATION USING THE ERYTHROCYTE OMEGA-3 INDEX: A STEP TOWARDS PERSONALIZED PREVENTION OF COGNITIVE DECLINE? 1,2 3 3 3 1,4 1,2 N. COLEY , R. RAMAN , M.C. DONOHUE , P.S. AISEN , B. VELLAS , S. ANDRIEU FOR THE MAPT/DSA STUDY GROUP* 1. INSERM-Toulouse University UMR1027, Toulouse France; 2. Toulouse University Hospital, Department of Epidemiology and Public Health, Toulouse, France; 3. Alzheimer’s Therapeutic Research Institute, University of Southern California, San Diego, CA, USA; 4. Toulouse University Hospital, Gérontopôle, Department of Geriatric Medicine, Toulouse, France. * members are listed at the end of the manuscript. Corresponding author: Nicola Coley, Faculté de Médecine, 37 allées Jules Guesde, 31000 Toulouse, France, Tel: +33 (0)5 61 14 56 80, Email: nicola.coley@inserm.fr Abstract: Objectives: to identify the optimal erythrocyte omega-3 index cut-off for predicting cognitive decline and/or polyunsaturated fatty acid (PUFA) treatment response, in order to better define the target population for future dementia prevention trials. Design & Setting: Secondary exploratory analysis of the randomized controlled MAPT prevention trial. Participants: 724 dementia-free subjects aged 70 or older with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Nutrition, Health & Aging Springer Journals

Defining the Optimal Target Population for Trials of Polyunsaturated Fatty Acid Supplementation Using the Erythrocyte Omega-3 Index: A Step Towards Personalized Prevention of Cognitive Decline?

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Serdi and Springer-Verlag France SAS, part of Springer Nature
Subject
Medicine & Public Health; Geriatrics/Gerontology; Nutrition; Aging; Neurosciences; Primary Care Medicine; Quality of Life Research
ISSN
1279-7707
eISSN
1760-4788
D.O.I.
10.1007/s12603-018-1052-2
Publisher site
See Article on Publisher Site

Abstract

J Nutr Health Aging. 2018;22(8):982-988 © Serdi and Springer-Verlag International SAS, part of Springer Nature DEFINING THE OPTIMAL TARGET POPULATION FOR TRIALS OF POLYUNSATURATED FATTY ACID SUPPLEMENTATION USING THE ERYTHROCYTE OMEGA-3 INDEX: A STEP TOWARDS PERSONALIZED PREVENTION OF COGNITIVE DECLINE? 1,2 3 3 3 1,4 1,2 N. COLEY , R. RAMAN , M.C. DONOHUE , P.S. AISEN , B. VELLAS , S. ANDRIEU FOR THE MAPT/DSA STUDY GROUP* 1. INSERM-Toulouse University UMR1027, Toulouse France; 2. Toulouse University Hospital, Department of Epidemiology and Public Health, Toulouse, France; 3. Alzheimer’s Therapeutic Research Institute, University of Southern California, San Diego, CA, USA; 4. Toulouse University Hospital, Gérontopôle, Department of Geriatric Medicine, Toulouse, France. * members are listed at the end of the manuscript. Corresponding author: Nicola Coley, Faculté de Médecine, 37 allées Jules Guesde, 31000 Toulouse, France, Tel: +33 (0)5 61 14 56 80, Email: nicola.coley@inserm.fr Abstract: Objectives: to identify the optimal erythrocyte omega-3 index cut-off for predicting cognitive decline and/or polyunsaturated fatty acid (PUFA) treatment response, in order to better define the target population for future dementia prevention trials. Design & Setting: Secondary exploratory analysis of the randomized controlled MAPT prevention trial. Participants: 724 dementia-free subjects aged 70 or older with

Journal

The Journal of Nutrition, Health & AgingSpringer Journals

Published: May 31, 2018

References

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