J Gastroenterol (2017) 52:1064–1074 DOI 10.1007/s00535-017-1334-1 O R I G IN AL ARTI CL E—LIV E R, PA NCREA S , A ND BIL I ARY T RA CT Deep sequencing analysis of quasispecies in the HBV pre-S region and its association with hepatocellular carcinoma 1,3 1,2 1 1,2 • • • • An-Ye Zhang Ching-Lung Lai Fung-Yu Huang Wai-Kay Seto 1,2 1,2 1,2 • • James Fung Danny Ka-Ho Wong Man-Fung Yuen Received: 19 August 2016 / Accepted: 21 March 2017 / Published online: 28 March 2017 Japanese Society of Gastroenterology 2017 Abstract intrapatient prevalence of pre-S deletions and point muta- Background The association between the evolution of tions (at codons 4, 27, and 167) compared with the control hepatitis B virus (HBV) quasispecies and the development patients (all p \ 0.05). Longitudinal observation in the sera of hepatocellular carcinoma (HCC) is unknown. of 14 HCC patients showed that quasispecies complexity Methods We used deep sequencing to examine the (p = 0.027 and 0.024 at the nucleotide level and the amino dynamics of HBV quasispecies and their relationship to acid level respectively) and diversity (p = 0.035 and 0.031 HCC development. Thirty-two chronic hepatitis B (CHB) at the
Journal of Gastroenterology – Springer Journals
Published: Mar 28, 2017
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