Deciphering the host-pathogen protein interface in chikungunya virus-mediated sickness

Deciphering the host-pathogen protein interface in chikungunya virus-mediated sickness Successful infection with chikungunya virus (CHIKV) depends largely on the ability of this virus to manipulate cellular processes in its favour through specific interactions with several host factors. The knowledge of virus-host interactions is of particular value for understanding the interface through which therapeutic strategies could be applied. In the current study, the authors have employed a computational method to study the protein interactions between CHIKV and both its human host and its mosquito vector. In this structure-based study, 2028 human and 86 mosquito proteins were predicted to interact with those of CHIKV through 3918 and 112 unique interactions, respectively. This approach could predict 40 % of the experimentally confirmed CHIKV-host interactions along with several novel interactions, suggesting the involvement of CHIKV in intracellular cell signaling, programmed cell death, and transcriptional and translational regulation. The data corresponded to those obtained in earlier studies for HIV and dengue viruses using the same methodology. This study provides a conservative set of potential interactions that can be employed for future experimental studies with a view to understanding CHIKV biology. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Deciphering the host-pathogen protein interface in chikungunya virus-mediated sickness

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Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1602-1
Publisher site
See Article on Publisher Site

Abstract

Successful infection with chikungunya virus (CHIKV) depends largely on the ability of this virus to manipulate cellular processes in its favour through specific interactions with several host factors. The knowledge of virus-host interactions is of particular value for understanding the interface through which therapeutic strategies could be applied. In the current study, the authors have employed a computational method to study the protein interactions between CHIKV and both its human host and its mosquito vector. In this structure-based study, 2028 human and 86 mosquito proteins were predicted to interact with those of CHIKV through 3918 and 112 unique interactions, respectively. This approach could predict 40 % of the experimentally confirmed CHIKV-host interactions along with several novel interactions, suggesting the involvement of CHIKV in intracellular cell signaling, programmed cell death, and transcriptional and translational regulation. The data corresponded to those obtained in earlier studies for HIV and dengue viruses using the same methodology. This study provides a conservative set of potential interactions that can be employed for future experimental studies with a view to understanding CHIKV biology.

Journal

Archives of VirologySpringer Journals

Published: Jun 1, 2013

References

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    Arpino, C; Curatolo, P; Rezza, G
  • Intrinsic factors affecting vector competence of mosquitoes for arboviruses
    Hardy, JL; Houk, EJ; Kramer, LD; Reeves, WC
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    Aloy, P; Russell, RB
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    Lu, L; Lu, H; Skolnick, J
  • Host pathogen protein interactions predicted by comparative modeling
    Davis, FP; Barkan, DT; Eswar, N; McKerrow, JH; Sali, A
  • Searching protein structure databases with DaliLite v. 3
    Holm, L; Kaariainen, S; Rosenstrom, P; Schenkel, A
  • Differential proteome analysis of chikungunya virus infected new-born mice tissues reveal implication of stress, inflammatory and apoptotic pathways in disease pathogenesis
    Dhanwani, R; Khan, M; Alam, SI; Rao, PVL; Parida, M
  • hnRNP proteins and the biogenesis of mRNA
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    Crotzer, VL; Blum, JS
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    Thorburn, A
  • ER stress and the unfolded protein response in intestinal inflammation
    McGuckin, MA; Eri, RD; Das, I; Lourie, R; Florin, TH
  • ROS mediated autophagy was involved in cancer cell death induced by novel copper(II) complex
    Guo, WJ; Ye, SS; Cao, N; Huang, J; Gao, J; Chen, QY
  • Stalling in mitosis and releasing the apoptotic brake
    Kurokawa, M; Kornbluth, S
  • Characterization of chikungunya virus infection in human neuroblastoma SH-SY5Y cells: role of apoptosis in neuronal cell death
    Dhanwani, R; Khan, M; Bhaskar, ASB
  • Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
    Schilte, C; Couderc, T; Chretien, F

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