DAWN and DEFUSE-3 trials: is time still important?

DAWN and DEFUSE-3 trials: is time still important? FDA-approved thrombectomy devices selected patients with occlusion of proximal Background. Endovascular thrombectomy were permitted. vessels in the anterior circulation up to 24 h has been proven effective in the first 6 h after This trial was also terminated early after suspected onset of symptoms. onset of stroke and large-vessel occlusion in for efficacy after 182 patients had un- Conclusion. Thrombectomy was shown to the anterior cerebral circulation. To date, it dergone randomization. Thrombectomy have high efficacy up to 24 h after suspected was not clear whether thrombectomy beyond symptom onset; however, patient selection was associated with a favorable shift in 6 h is also beneficial. is very complex. Early detection of large- Methods. A summary of the prospective the distribution of functional outcomes vessel occlusion is of utmost importance. The DAWN (DWI or CTP Assessment with on the modified Rankin scale at 90 days cooperation between existing neurovascular Clinical Mismatch in the Triage of Wake-Up and a higher percentage of patients who and Late Presenting Strokes Undergoing networks should be adapted according to were functionally independent, defined Neurointervention with Trevo) and DEFUSE- these new findings. 3 (Endovascular Therapy Following Imaging as a score on the modified Rankin scale of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Der Radiologe Springer Journals

DAWN and DEFUSE-3 trials: is time still important?

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Publisher
Springer Medizin
Copyright
Copyright © 2018 by Springer Medizin Verlag GmbH, ein Teil von Springer Nature
Subject
Medicine & Public Health; Imaging / Radiology; General Practice / Family Medicine
ISSN
0033-832X
eISSN
1432-2102
D.O.I.
10.1007/s00117-018-0406-4
Publisher site
See Article on Publisher Site

Abstract

FDA-approved thrombectomy devices selected patients with occlusion of proximal Background. Endovascular thrombectomy were permitted. vessels in the anterior circulation up to 24 h has been proven effective in the first 6 h after This trial was also terminated early after suspected onset of symptoms. onset of stroke and large-vessel occlusion in for efficacy after 182 patients had un- Conclusion. Thrombectomy was shown to the anterior cerebral circulation. To date, it dergone randomization. Thrombectomy have high efficacy up to 24 h after suspected was not clear whether thrombectomy beyond symptom onset; however, patient selection was associated with a favorable shift in 6 h is also beneficial. is very complex. Early detection of large- Methods. A summary of the prospective the distribution of functional outcomes vessel occlusion is of utmost importance. The DAWN (DWI or CTP Assessment with on the modified Rankin scale at 90 days cooperation between existing neurovascular Clinical Mismatch in the Triage of Wake-Up and a higher percentage of patients who and Late Presenting Strokes Undergoing networks should be adapted according to were functionally independent, defined Neurointervention with Trevo) and DEFUSE- these new findings. 3 (Endovascular Therapy Following Imaging as a score on the modified Rankin scale of

Journal

Der RadiologeSpringer Journals

Published: May 28, 2018

References

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