Daratumumab Reactions 1680, p113 - 2 Dec 2017 ★ S First report of pulmonary oedema: case report In a retrospective study of 126 patients, a patient was described [age and sex not stated], who developed pulmonary oedema following treatment with daratumumab. The patient, who had a history of multiple myeloma, was started on IV infusion of daratumumab 16 mg/kg body weight weekly for the first eight weeks, every two weeks for the next 16 weeks and then monthly. Following daratumumab infusion, the patient developed pulmonary oedema, which required non-invasive mechanical ventilation [time to reaction onset and outcome not stated]. Author comment: "One patient developed pulmonary edema following daratumumab infusion and required noninvasive mechanical ventilation." Lakshman A, et al. Efficacy of daratumumab-based therapies in patients with relapsed, refractory multiple myeloma treated outside of clinical trials. American Journal of Hematology 92: 1146-1155, No. 11, Nov 2017. Available from: URL: http://doi.org/10.1002/ajh.24883 - USA 803284996 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of pulmonary oedema associated with daratumumab. The WHO ADR database contained 5 reports of pulmonary oedema associated with 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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