Daily supplementation with fresh pomegranate juice increases paraoxonase 1 expression and activity in mice fed a high-fat diet

Daily supplementation with fresh pomegranate juice increases paraoxonase 1 expression and... Eur J Nutr (2018) 57:383–389 DOI 10.1007/s00394-017-1394-2 ORIGINAL CONTRIBUTION Daily supplementation with fresh pomegranate juice increases paraoxonase 1 expression and activity in mice fed a high-fat diet 1 1 2 3 D. Estrada-Luna  · E. Martínez-Hinojosa  · J. C. Cancino-Diaz  · H. Belefant-Miller  · 1 1 G. López-Rodríguez  · G. Betanzos-Cabrera   Received: 2 June 2016 / Accepted: 2 February 2017 / Published online: 27 February 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract PON1 activity of the unsupplemented group. In addition, Purpose Studies have found that pomegranate juice (PJ) PJ-supplemented animals had the lowest body weight and consumption increases the binding of high-density lipo- significantly reduced cholesterol and triacylglycerol lev - proteins (HDL) to paraoxonase 1 (PON1), thus increasing els, although the tricylglycerol levels were not consistently the catalytic activity of this enzyme. PON1 is an antioxi- decreased. dant arylesterase synthesized in the liver and transported Conclusions These results suggest that PJ protects against in plasma in association with HDL. Decreased levels of the effects of a high-fat diet in body weight, and cholesterol PON1 are associated with higher levels of cholesterol. We levels. determined the effects of PJ on body weight, cholesterol, and triacylglycerols through 5 months of supplementation. Keywords Pomegranate juice · Paraoxonase1 · High-fat In addition, the effect of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Nutrition Springer Journals

Daily supplementation with fresh pomegranate juice increases paraoxonase 1 expression and activity in mice fed a high-fat diet

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Chemistry; Nutrition
ISSN
1436-6207
eISSN
1436-6215
D.O.I.
10.1007/s00394-017-1394-2
Publisher site
See Article on Publisher Site

Abstract

Eur J Nutr (2018) 57:383–389 DOI 10.1007/s00394-017-1394-2 ORIGINAL CONTRIBUTION Daily supplementation with fresh pomegranate juice increases paraoxonase 1 expression and activity in mice fed a high-fat diet 1 1 2 3 D. Estrada-Luna  · E. Martínez-Hinojosa  · J. C. Cancino-Diaz  · H. Belefant-Miller  · 1 1 G. López-Rodríguez  · G. Betanzos-Cabrera   Received: 2 June 2016 / Accepted: 2 February 2017 / Published online: 27 February 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract PON1 activity of the unsupplemented group. In addition, Purpose Studies have found that pomegranate juice (PJ) PJ-supplemented animals had the lowest body weight and consumption increases the binding of high-density lipo- significantly reduced cholesterol and triacylglycerol lev - proteins (HDL) to paraoxonase 1 (PON1), thus increasing els, although the tricylglycerol levels were not consistently the catalytic activity of this enzyme. PON1 is an antioxi- decreased. dant arylesterase synthesized in the liver and transported Conclusions These results suggest that PJ protects against in plasma in association with HDL. Decreased levels of the effects of a high-fat diet in body weight, and cholesterol PON1 are associated with higher levels of cholesterol. We levels. determined the effects of PJ on body weight, cholesterol, and triacylglycerols through 5 months of supplementation. Keywords Pomegranate juice · Paraoxonase1 · High-fat In addition, the effect of

Journal

European Journal of NutritionSpringer Journals

Published: Feb 27, 2017

References

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