Eur J Nutr (2018) 57:383–389 DOI 10.1007/s00394-017-1394-2 ORIGINAL CONTRIBUTION Daily supplementation with fresh pomegranate juice increases paraoxonase 1 expression and activity in mice fed a high-fat diet 1 1 2 3 D. Estrada-Luna · E. Martínez-Hinojosa · J. C. Cancino-Diaz · H. Belefant-Miller · 1 1 G. López-Rodríguez · G. Betanzos-Cabrera Received: 2 June 2016 / Accepted: 2 February 2017 / Published online: 27 February 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract PON1 activity of the unsupplemented group. In addition, Purpose Studies have found that pomegranate juice (PJ) PJ-supplemented animals had the lowest body weight and consumption increases the binding of high-density lipo- significantly reduced cholesterol and triacylglycerol lev - proteins (HDL) to paraoxonase 1 (PON1), thus increasing els, although the tricylglycerol levels were not consistently the catalytic activity of this enzyme. PON1 is an antioxi- decreased. dant arylesterase synthesized in the liver and transported Conclusions These results suggest that PJ protects against in plasma in association with HDL. Decreased levels of the effects of a high-fat diet in body weight, and cholesterol PON1 are associated with higher levels of cholesterol. We levels. determined the effects of PJ on body weight, cholesterol, and triacylglycerols through 5 months of supplementation. Keywords Pomegranate juice · Paraoxonase1 · High-fat In addition, the effect of
European Journal of Nutrition – Springer Journals
Published: Feb 27, 2017
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