Digestive Diseases and Sciences (2018) 63:549–550 https://doi.org/10.1007/s10620-017-4865-7 EDITORIAL Cytologic Diagnosis of Biliary Strictures: FISH or Cut the Sensitivity Rate? 1 2 Douglas G. Adler · Benjamin Witt Published online: 12 January 2018 © Springer Science+Business Media, LLC, part of Springer Nature 2018 The definitive diagnosis of a malignant biliary stricture with the nuclear DNA of individual cells in a cytologic remains difficult, even if cancer is strongly suspected. sample obtained from brushings of a biliary stricture. The Whereas some subsets of patients are relatively easy to diag- most commonly clinically used FISH-based test adopts the nose (i.e., those with pancreatic masses causing extrahepatic UroVysion™ test, originally developed for detecting urothe- biliary obstruction), many patients can defy even the most lial carcinoma in voided urine specimens, to biliary brush- exhaustive diagnostic efforts. Specifically, cholangiocarci - ings. The FISH probes detect polysomy of chromosomes noma arising in patients with and without primary scleros- 3, 7, and 17 and may also include detection of deletion of ing cholangitis (PSC) can be extremely difficult to diagnose, chromosome locus 9p21, genetic abnormalities typical of since these lesions are often hypocellular due to fibrosis and many types of epithelial cancers, including those affecting an underlying desmoplastic reaction. These tumor features the
Digestive Diseases and Sciences – Springer Journals
Published: Jan 12, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera