Mammalian Genome 12, 397–399 (2001). DOI: 10.1007/s003350020004 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 Cytogenetic and radiation hybrid mapping reveals conserved synteny and gene order between human Chromosome 21 and pig Chromosome 13 1,2 2 1 3 1 Christopher K. Tuggle, Carine Gene ˆt, Xian-Wei Shi, Patrick Chardon, Ibis Sanchez-Serrano, 1 2 2 Grant Cravens, Denis Milan, Martine Yerle Department of Animal Science, 2255 Kildee Hall, Iowa State University, Ames, IA, 50011 USA Laboratoire de Genetique Cellulaire, INRA, Castanet-Tolosan, France Laboratoire de Radiobiologie et d’Etude du Genome, INRA-CEA, Jouy-en-Josas, France Received: 20 October 2000 / Accepted: 21 December 2000 Comparative genome studies across vertebrate species can shed al. 1992) that indicate both conservation and rearrangements of light on chromosome evolution as well as provide practical infor- these genes during evolution. Although very limited Hsap21 gene mation for understanding genome structure. Chromosome painting mapping data exist for the pig, additional comparative mapping in experiments between the human and pig genomes have revealed this region would be informative owing to the wealth of compara- extensive conservation of synteny (Rettenberger et al. 1995; tive data in other species, including the recent completion of the Fro ¨ nicke et al. 1996;
Mammalian Genome – Springer Journals
Published: May 1, 2001
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