Cytogenetic Aberrations in the Cells of Liver and Spermatogenic Epithelium in Senescence Accelerated SAMP1 and SAMR1 Mice

Cytogenetic Aberrations in the Cells of Liver and Spermatogenic Epithelium in Senescence... It was shown that during ontogenesis, the mice prone to (SAMP1) and resistant (SAMR1) against accelerates senescence did not differ substantially in the frequency of cytogenetic aberrations in the hepatocytes and spermatogenic cells (spermatogonia and round spermatids). These data suggest that in the mice of both lines, the processes of appearance, development, and functioning of complex biological systems, such as liver and spermatogonic epithelium take place against the background of high genetic instability. The role of genetic instability in senescence is discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Developmental Biology Springer Journals

Cytogenetic Aberrations in the Cells of Liver and Spermatogenic Epithelium in Senescence Accelerated SAMP1 and SAMR1 Mice

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2002 by MAIK “Nauka/Interperiodica”
Subject
Life Sciences; Animal Anatomy / Morphology / Histology
ISSN
1062-3604
eISSN
1608-3326
D.O.I.
10.1023/A:1021158727040
Publisher site
See Article on Publisher Site

Abstract

It was shown that during ontogenesis, the mice prone to (SAMP1) and resistant (SAMR1) against accelerates senescence did not differ substantially in the frequency of cytogenetic aberrations in the hepatocytes and spermatogenic cells (spermatogonia and round spermatids). These data suggest that in the mice of both lines, the processes of appearance, development, and functioning of complex biological systems, such as liver and spermatogonic epithelium take place against the background of high genetic instability. The role of genetic instability in senescence is discussed.

Journal

Russian Journal of Developmental BiologySpringer Journals

Published: Oct 13, 2004

References

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