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It was shown that during ontogenesis, the mice prone to (SAMP1) and resistant (SAMR1) against accelerates senescence did not differ substantially in the frequency of cytogenetic aberrations in the hepatocytes and spermatogenic cells (spermatogonia and round spermatids). These data suggest that in the mice of both lines, the processes of appearance, development, and functioning of complex biological systems, such as liver and spermatogonic epithelium take place against the background of high genetic instability. The role of genetic instability in senescence is discussed.
Russian Journal of Developmental Biology – Springer Journals
Published: Oct 13, 2004
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