Cytarabine/etoposide Reactions 1680, p106 - 2 Dec 2017 Vitreous haemorrhage and hypokalaemia: 2 case report In a retrospective observational study of 46 patients, two patients [ages and sexes not stated] were described, who developed vitreous haemorrhage (one patient) and hypokalaemia (one patient) during treatment with etoposide and cytarabine [duration of treatments to reaction onsets and outcomes not stated]. The patients, who had a history of lymphoma, were scheduled to undergo peripheral blood stem cell harvest. The stem cell mobilisation was carried out with continuous infusion of etoposide 100 mg/m /day and continuous infusion of cytarabine 100 mg/m /day, both were administered from day one to day four. However, one patient developed grade III vitreous haemorrhage and one patient developed grade III hypokalaemia. Author comment: "Only two patients developed grade 3 non-hematological adverse events (one vitreous hemorrhage and one hypokalemia). . .Other non-hematological severe adverse events were rarely observed; therefore, the toxicity of the EC regimen was acceptable on the whole." Koyama D, et al. Effective chemomobilization with etoposide and cytarabine (EC regimen) in lymphoma patients: A single-center, retrospective, observational study. Japanese Journal of Clinical Oncology 47: 820-825, No. 9, Sep 2017. Available from: URL: - Japan 803284128 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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