Cytarabine/daunorubicin

Cytarabine/daunorubicin Reactions 1680, p105 - 2 Dec 2017 Optic neuropathy and bull’s eye maculopathy: case report A 50-year-old man developed optic neuropathy and bull’s eye maculopathy during treatment with cytarabine and daunorubicin [dosages not stated]. The man, who had a history of acute myeloid leukaemia, received treatment with IV cytarabine and daunorubicin. After three cycles of cytarabine and daunorubicin, he experienced an abrupt decrease in vision in his left eye. The man started receiving treatment with prednisolone. Later, the treatment was discontinued. Six weeks after the appearance of symptoms, his best corrected visual acuity was 20/20 in the right eye and 20/30 in the left eye. Colour vision was defective in both the eyes. A relative afferent pupillary defect was noted in his left eye. There was pallor of both the optic discs with a cup-to-disc ratio of 0.3. An early ’bull’s eye’ pattern was noted in both the eyes. Automated perimetry showed peripheral depressed points in the right eye and constriction of the visual field in the left eye with a small temporal island of vision. Optical coherence tomography (OCT) demonstrated thinning of the retinal nerve fibre layer in both the eyes. The OCT of the macula revealed thinning and alteration of the foveal contour in both the eyes. Fundus fluorescein angiography showed window defects with mottled hyper fluorescence in the para foveal region in both the eyes. Disc staining was observed in both the eyes. He was diagnosed with chemotherapy induced optic neuropathy with maculopathy [durations of treatments to reactions onset not stated]. He received different chemotherapy treatment secondary to bone marrow transplantation. At follow-up, he showed no worsening of vision or progression of optic nerve and macular changes. Author comment: "We report a case of Presumed Chemotherapy-Induced optic neuropathy and maculopathy secondary to treatment with cytarabine and daunorubicin for Acute Myeloid Leukaemia (AML)." Mathew DJ, et al. Presumed chemotherapy-induced optic neuropathy and maculopathy: A case report. Open Ophthalmology Journal 11: 298-304, Sep 2017. Available from: URL: http://doi.org/10.2174/1874364101711010298 - India 803285172 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Cytarabine/daunorubicin

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
Free
1 page
Loading next page...
1 Page
 
/lp/springer_journal/cytarabine-daunorubicin-2EdLwiHCBl
Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39036-8
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p105 - 2 Dec 2017 Optic neuropathy and bull’s eye maculopathy: case report A 50-year-old man developed optic neuropathy and bull’s eye maculopathy during treatment with cytarabine and daunorubicin [dosages not stated]. The man, who had a history of acute myeloid leukaemia, received treatment with IV cytarabine and daunorubicin. After three cycles of cytarabine and daunorubicin, he experienced an abrupt decrease in vision in his left eye. The man started receiving treatment with prednisolone. Later, the treatment was discontinued. Six weeks after the appearance of symptoms, his best corrected visual acuity was 20/20 in the right eye and 20/30 in the left eye. Colour vision was defective in both the eyes. A relative afferent pupillary defect was noted in his left eye. There was pallor of both the optic discs with a cup-to-disc ratio of 0.3. An early ’bull’s eye’ pattern was noted in both the eyes. Automated perimetry showed peripheral depressed points in the right eye and constriction of the visual field in the left eye with a small temporal island of vision. Optical coherence tomography (OCT) demonstrated thinning of the retinal nerve fibre layer in both the eyes. The OCT of the macula revealed thinning and alteration of the foveal contour in both the eyes. Fundus fluorescein angiography showed window defects with mottled hyper fluorescence in the para foveal region in both the eyes. Disc staining was observed in both the eyes. He was diagnosed with chemotherapy induced optic neuropathy with maculopathy [durations of treatments to reactions onset not stated]. He received different chemotherapy treatment secondary to bone marrow transplantation. At follow-up, he showed no worsening of vision or progression of optic nerve and macular changes. Author comment: "We report a case of Presumed Chemotherapy-Induced optic neuropathy and maculopathy secondary to treatment with cytarabine and daunorubicin for Acute Myeloid Leukaemia (AML)." Mathew DJ, et al. Presumed chemotherapy-induced optic neuropathy and maculopathy: A case report. Open Ophthalmology Journal 11: 298-304, Sep 2017. Available from: URL: http://doi.org/10.2174/1874364101711010298 - India 803285172 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off