Reactions 1704, p127 - 2 Jun 2018 Intracranial meningioma: case report A 41-year-old transwoman (male-to-female transsexual) developed intracranial meningioma following treatment with cyproterone [cyproterone acetate] and estradiol. The patient, who was receiving hormone suppression treatment with cyproterone 50mg per day [route not stated] and estradiol gel 1mg and thereafter 2mg and up to 3mg per day for the last nine years, presented with partial inability to read and some prosopagnosia episodes for one year. The patient’s medical history included ganglioglioma diagnosed four years earlier and subsequent partial tumour resection. Upon current presentation, an MRI scan revealed a 3cm left occipital mass. Cyproterone was withdrawn and it was substituted with leuprorelin [leuprorelina acetate], which was given in combination with transdermal estradiol. The patient underwent a second surgery for radical tumour resection. Histological examination revealed meningothelial meningioma (WHO, grade I). The meningioma was found to be strongly progesterone receptor-positive and slightly estrogen receptor- positive, with an MIB-1 index of 1%. The patient continued receiving treatment with leuprorelin and estradiol. One year later, a follow up MRI revealed no recurrence of the tumour. Author comment: "We report the ninth known case of growth of intracranial meningioma in a transwoman who had been taking feminizing hormones consisting of estradiol and cyproterone for the previous nine years. At histological examination, the meningioma resulted in high positivity (90%) for progestin receptors with low positivity for estrogen receptors (20%) thereby confirming the hypothesis of a link between meningioma and sex steroids." Mancini I, et al. Presentation of a meningioma in a transwoman after nine years of cyproterone acetate and estradiol intake: case report and literature review. Gynecological Endocrinology 34: 456-459, No. 6, Jun 2018. Available from: URL: http://doi.org/10.1080/09513590.2017.1395839 - Italy 803323844 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera