Cyproterone/estradiol

Cyproterone/estradiol Reactions 1704, p127 - 2 Jun 2018 Intracranial meningioma: case report A 41-year-old transwoman (male-to-female transsexual) developed intracranial meningioma following treatment with cyproterone [cyproterone acetate] and estradiol. The patient, who was receiving hormone suppression treatment with cyproterone 50mg per day [route not stated] and estradiol gel 1mg and thereafter 2mg and up to 3mg per day for the last nine years, presented with partial inability to read and some prosopagnosia episodes for one year. The patient’s medical history included ganglioglioma diagnosed four years earlier and subsequent partial tumour resection. Upon current presentation, an MRI scan revealed a 3cm left occipital mass. Cyproterone was withdrawn and it was substituted with leuprorelin [leuprorelina acetate], which was given in combination with transdermal estradiol. The patient underwent a second surgery for radical tumour resection. Histological examination revealed meningothelial meningioma (WHO, grade I). The meningioma was found to be strongly progesterone receptor-positive and slightly estrogen receptor- positive, with an MIB-1 index of 1%. The patient continued receiving treatment with leuprorelin and estradiol. One year later, a follow up MRI revealed no recurrence of the tumour. Author comment: "We report the ninth known case of growth of intracranial meningioma in a transwoman who had been taking feminizing hormones consisting of estradiol and cyproterone for the previous nine years. At histological examination, the meningioma resulted in high positivity (90%) for progestin receptors with low positivity for estrogen receptors (20%) thereby confirming the hypothesis of a link between meningioma and sex steroids." Mancini I, et al. Presentation of a meningioma in a transwoman after nine years of cyproterone acetate and estradiol intake: case report and literature review. Gynecological Endocrinology 34: 456-459, No. 6, Jun 2018. Available from: URL: http://doi.org/10.1080/09513590.2017.1395839 - Italy 803323844 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Cyproterone/estradiol

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46770-3
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p127 - 2 Jun 2018 Intracranial meningioma: case report A 41-year-old transwoman (male-to-female transsexual) developed intracranial meningioma following treatment with cyproterone [cyproterone acetate] and estradiol. The patient, who was receiving hormone suppression treatment with cyproterone 50mg per day [route not stated] and estradiol gel 1mg and thereafter 2mg and up to 3mg per day for the last nine years, presented with partial inability to read and some prosopagnosia episodes for one year. The patient’s medical history included ganglioglioma diagnosed four years earlier and subsequent partial tumour resection. Upon current presentation, an MRI scan revealed a 3cm left occipital mass. Cyproterone was withdrawn and it was substituted with leuprorelin [leuprorelina acetate], which was given in combination with transdermal estradiol. The patient underwent a second surgery for radical tumour resection. Histological examination revealed meningothelial meningioma (WHO, grade I). The meningioma was found to be strongly progesterone receptor-positive and slightly estrogen receptor- positive, with an MIB-1 index of 1%. The patient continued receiving treatment with leuprorelin and estradiol. One year later, a follow up MRI revealed no recurrence of the tumour. Author comment: "We report the ninth known case of growth of intracranial meningioma in a transwoman who had been taking feminizing hormones consisting of estradiol and cyproterone for the previous nine years. At histological examination, the meningioma resulted in high positivity (90%) for progestin receptors with low positivity for estrogen receptors (20%) thereby confirming the hypothesis of a link between meningioma and sex steroids." Mancini I, et al. Presentation of a meningioma in a transwoman after nine years of cyproterone acetate and estradiol intake: case report and literature review. Gynecological Endocrinology 34: 456-459, No. 6, Jun 2018. Available from: URL: http://doi.org/10.1080/09513590.2017.1395839 - Italy 803323844 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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