Reactions 1704, p126 - 2 Jun 2018 Pneumocystis pneumonia: 30 case reports In a retrospective study, 30 patients aged between 18 93 years (21 women and nine men) were described, who developed pneumocystis pneumonia (PCP) following treatment with prednisone and cyclophosphamide [routes not stated; not all dosages and outcomes stated]. The patients had been diagnosed with autoimmune diseases like systemic lupus erythematosus, granulomatosis with polyangiitis, rheumatoid arthritis, microscopic polyangiitis, systemic sclerosis, dermatomyositis, temporal arteritis, cryoglobulinaemic vasculitis or Sjogren syndrome. Subsequently, the patients started receiving treatment with prednisone and some patients received cyclophosphamide pulse along with prednisone. The patients developed PCP within 0.9 to 10.8 months. Only one patient had received prophylaxis with cotrimoxazole, which was discontinued prematurely due to unspecified adverse drug reaction. Amongst the 30 patients, 11 patients died due to pneumocystis pneumonia. Author comment: "The most important risk factor for PCP in non-HIV patients is the use of immunosuppressive drugs, especially corticosteroids." "[C]oncomitant cyclophosphamide pulse and baseline lymphopenia were associated with an increased incidence of PCP." Park JW, et al. Prophylactic effect of trimethoprim-sulfamethoxazole for pneumocystis pneumonia in patients with rheumatic diseases exposed to prolonged high-dose glucocorticoids. Annals of the Rheumatic Diseases 77: 644-649, No. 5, May 2018. Available from: URL: http://doi.org/10.1136/annrheumdis-2017-211796 - South Korea 803323313 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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