Reactions 1704, p123 - 2 Jun 2018 Gastrointestinal side effects: case report A 49-year-old woman developed gastrointestinal side effects during treatment with cyclophosphamide for hypertrophic pachymeningitis. The woman was diagnosed with hypertrophic pachymeningitis at the age of 48 years. She presented at the age of 49 years due to recurrence of hypertrophic pachymeningitis. She was receiving prednisolone. Based on the biopsy of the nasal mucosa, she was diagnosed with a limited form granulomatosis with polyangiitis. Therefore, monthly treatment with IV cyclophosphamide was initiated and administered three times at a dose of 600mg, 800mg and 800mg. Subsequently, she experienced gastrointestinal side effects [time to reaction onset not stated]. Therefore, the woman declined further treatment with cyclophosphamide. Later, she developed simultaneous multiple intracerebral haemorrhages and consciousness impairment at the age of 50 years secondary to granulomatosis with polyangiitis [outcome of ADR not stated]. Author comment: "Monthly intravenous cyclophosphamide therapy was therefore initiated and administered 3 times (at doses of 600 mg, 800 mg, and 800 mg), after which she declined further [cyclophosphamide] because of gastrointestinal side effects." Kato E, et al. Granulomatosis with polyangiitis complicated by hypertrophic pachymeningitis presenting with simultaneous multiple intracerebral hemorrhages. Internal Medicine 57: 1167-1172, No. 8, 2018. Available from: URL: http:// doi.org/10.2169/internalmedicine.9660-17 - Japan 803322853 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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