Keywords 4-Thiazolidinones b-Cyclodextrin-SO H Green synthesis & Murlidhar S. Shingare email@example.com Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, India Wockhardt Research Centre, Aurangabad 431 210, India 123 10028 M. A. Chaudhari et al. Introduction 4-Thiazolidinones are among the most important nitrogen and sulfur-containing heterocycles. Among diverse, medicinally relevant structures, 4-thiazolidinone derivatives are known for their wide range of pharmacological activity, for example antibacterial , antimalarial , antitubercular [3–5], anticancer , anti- inﬂammatory , antiproliferative [8, 9], anticonvulsant [10, 11], and antidiabetic  activity, and as COX-1 and COX-2 inhibitors [13, 14]. The most common approach for synthesis of the thiazolidinone ring involves three-component reaction of an aldehyde, an amine, and thioglycolic acid in one or two steps. Researchers have dedicated much effort to synthesis of 4-thiazolidinones using benzene or toluene [15, 16], ionic liquids [17, 18], PEG , ZnCl , Bi(SCH COOH) , protic acid , zeolite , silica gel , and 2 3 Saccharomyces cerevisiae  as catalysts. However, some of these procedures have major disadvantages, for example prolonged reaction time, use of special apparatus (Dean and Stark assembly), use of expensive and environmentally toxic catalysts and solvents, and low or moderate
Research on Chemical Intermediates – Springer Journals
Published: Apr 12, 2015
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