β-Cyclodextrin-SO3H-catalyzed facile and highly efficient synthesis of 4-thiazolidinones under solvent free conditions

β-Cyclodextrin-SO3H-catalyzed facile and highly efficient synthesis of 4-thiazolidinones under... Keywords 4-Thiazolidinones  b-Cyclodextrin-SO H  Green synthesis & Murlidhar S. Shingare prof_msshingare@rediffmail.com Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, India Wockhardt Research Centre, Aurangabad 431 210, India 123 10028 M. A. Chaudhari et al. Introduction 4-Thiazolidinones are among the most important nitrogen and sulfur-containing heterocycles. Among diverse, medicinally relevant structures, 4-thiazolidinone derivatives are known for their wide range of pharmacological activity, for example antibacterial [1], antimalarial [2], antitubercular [3–5], anticancer [6], anti- inflammatory [7], antiproliferative [8, 9], anticonvulsant [10, 11], and antidiabetic [12] activity, and as COX-1 and COX-2 inhibitors [13, 14]. The most common approach for synthesis of the thiazolidinone ring involves three-component reaction of an aldehyde, an amine, and thioglycolic acid in one or two steps. Researchers have dedicated much effort to synthesis of 4-thiazolidinones using benzene or toluene [15, 16], ionic liquids [17, 18], PEG [19], ZnCl [20], Bi(SCH COOH) [21], protic acid [22], zeolite [23], silica gel [24], and 2 3 Saccharomyces cerevisiae [25] as catalysts. However, some of these procedures have major disadvantages, for example prolonged reaction time, use of special apparatus (Dean and Stark assembly), use of expensive and environmentally toxic catalysts and solvents, and low or moderate http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

β-Cyclodextrin-SO3H-catalyzed facile and highly efficient synthesis of 4-thiazolidinones under solvent free conditions

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Publisher
Springer Netherlands
Copyright
Copyright © 2015 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-015-2010-9
Publisher site
See Article on Publisher Site

Abstract

Keywords 4-Thiazolidinones  b-Cyclodextrin-SO H  Green synthesis & Murlidhar S. Shingare prof_msshingare@rediffmail.com Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, India Wockhardt Research Centre, Aurangabad 431 210, India 123 10028 M. A. Chaudhari et al. Introduction 4-Thiazolidinones are among the most important nitrogen and sulfur-containing heterocycles. Among diverse, medicinally relevant structures, 4-thiazolidinone derivatives are known for their wide range of pharmacological activity, for example antibacterial [1], antimalarial [2], antitubercular [3–5], anticancer [6], anti- inflammatory [7], antiproliferative [8, 9], anticonvulsant [10, 11], and antidiabetic [12] activity, and as COX-1 and COX-2 inhibitors [13, 14]. The most common approach for synthesis of the thiazolidinone ring involves three-component reaction of an aldehyde, an amine, and thioglycolic acid in one or two steps. Researchers have dedicated much effort to synthesis of 4-thiazolidinones using benzene or toluene [15, 16], ionic liquids [17, 18], PEG [19], ZnCl [20], Bi(SCH COOH) [21], protic acid [22], zeolite [23], silica gel [24], and 2 3 Saccharomyces cerevisiae [25] as catalysts. However, some of these procedures have major disadvantages, for example prolonged reaction time, use of special apparatus (Dean and Stark assembly), use of expensive and environmentally toxic catalysts and solvents, and low or moderate

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Apr 12, 2015

References

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