World J Urol (2017) 35:1213–1221 DOI 10.1007/s00345-016-1996-y ORIGINAL ARTICLE CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression 1,2,3 1,2,3 1,2,3 1,2,3 Chuangzhong Deng · Jieping Chen · Shengjie Guo · Yanjun Wang · 1,2,3 1,2,3 4 2,3,5 Qianghua Zhou · Zaishang Li · Xingping Yang · Xingsu Yu · 2,3,5 1,2,3 1,2,3 1,2,3 Zhenfeng Zhang · Fangjian Zhou · Hui Han · Kai Yao Received: 8 October 2016 / Accepted: 21 December 2016 / Published online: 19 January 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract assay. Protein and mRNA levels of full-length AR (AR-FL) Purpose The aberrant expression of casein kinase 2 and AR-V7 were determined by qPCR and western blot, (CK2) has been reported to be involved in the tumorigen- respectively. The nuclear translocation of p50 and p65 was esis and progression of prostate cancer. The inhibition of assessed to reflect the activity of the NF-κB pathway. CK2 activity represses androgen-dependent prostate cancer Results CX4945 reduced the proliferation of CRPC cells cells by attenuating the androgen receptor (AR) signaling in a dose-dependent and time-dependent manner. AR-V7 pathway. In this study, we examined the effect of CK2 inhi- rather than AR-FL was downregulated by CX4945 in both bition in castration-resistant prostate cancer (CRPC) cells, the mRNA and protein
World Journal of Urology – Springer Journals
Published: Jan 19, 2017
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