CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression

CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7... World J Urol (2017) 35:1213–1221 DOI 10.1007/s00345-016-1996-y ORIGINAL ARTICLE CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression 1,2,3 1,2,3 1,2,3 1,2,3 Chuangzhong Deng  · Jieping Chen  · Shengjie Guo  · Yanjun Wang  · 1,2,3 1,2,3 4 2,3,5 Qianghua Zhou  · Zaishang Li  · Xingping Yang  · Xingsu Yu  · 2,3,5 1,2,3 1,2,3 1,2,3 Zhenfeng Zhang  · Fangjian Zhou  · Hui Han  · Kai Yao   Received: 8 October 2016 / Accepted: 21 December 2016 / Published online: 19 January 2017 © Springer-Verlag Berlin Heidelberg 2017 Abstract assay. Protein and mRNA levels of full-length AR (AR-FL) Purpose The aberrant expression of casein kinase 2 and AR-V7 were determined by qPCR and western blot, (CK2) has been reported to be involved in the tumorigen- respectively. The nuclear translocation of p50 and p65 was esis and progression of prostate cancer. The inhibition of assessed to reflect the activity of the NF-κB pathway. CK2 activity represses androgen-dependent prostate cancer Results CX4945 reduced the proliferation of CRPC cells cells by attenuating the androgen receptor (AR) signaling in a dose-dependent and time-dependent manner. AR-V7 pathway. In this study, we examined the effect of CK2 inhi- rather than AR-FL was downregulated by CX4945 in both bition in castration-resistant prostate cancer (CRPC) cells, the mRNA and protein World Journal of Urology Springer Journals

CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression

Loading next page...
Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Medicine & Public Health; Urology; Nephrology; Oncology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial