Curr Diab Rep (2017) 17: 128 https://doi.org/10.1007/s11892-017-0967-z PHARMACOLOGIC TREATMENT OF TYPE 2 DIABETES (HE LEBOVITZ AND G BAHTIYAR, SECTION EDITORS) Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications? 1 2,3 1,4,5 1,4,6 Magnus F. Grøndahl & Damien J. Keating & Tina Vilsbøll & Filip K. Knop Published online: 28 October 2017 Springer Science+Business Media, LLC 2017 Abstract underestimated role in the efficacy and safety of several Purpose of Review Hyperglucagonemia contributes signifi- glucose-lowering drugs. cantly to hyperglycemia in type 2 diabetes and suppressed Summary Numerous drugs currently available to diabetologists glucagon levels may increase the risk of hypoglycemia. are capable of altering glucagon secretion: metformin, sulfonyl- Here, we give a brief overview of glucagon physiology and urea compounds, insulin, glucagon-like peptide-1 receptor ago- the role of glucagon in the pathophysiology of type 2 diabetes nists, dipeptidyl peptidase-4 inhibitors, sodium-glucose and provide insights into how antidiabetic drugs influence cotransporter 2 inhibitors and amylin mimetics. Their diverse glucagon secretion as well as a perspective on the future of effects on glucagon secretion are of importance for their indi- glucagon-targeting drugs. vidual efficacy and safety profiles. Understanding how these Recent Findings Several older as well as
Current Diabetes Reports – Springer Journals
Published: Oct 28, 2017
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