Arch Virol (2005) 150: 1047–1057 DOI 10.1007/s00705-005-0493-1 Brief Review C. M. Hendekli UNIDOST A.S., Istanbul, Turkey Received November 19, 2004; accepted January 4, 2005 Published online March 3, 2005 Springer-Verlag 2005 Introduction Rabies, originating from the Greek word “Lyssa” meaning “frenzy”, is a viral disease affecting the CNS (central nervous system) and is transmitted by the salvia of a rabid mammal. Rabies virus has been classiﬁed as a species within the genus Lyssavirus within the family Rhabdoviridae. Despite the invention and application of the ﬁrst rabies vaccine on July 6, 1885 by Louis Pasteur, human rabies, which ends up with an extremely painful and torturous death, is still a problem in the world. WHO (World Health Organization) reports over 30,000 human deaths per year from rabies, however the actual number including the unreported cases is estimated to be signiﬁcantly above 60,000 deaths, mostly occuring in India and China . Theoretically, rabies can be transmitted by any mammal. Humans can almost only be infected when an infected animal’s salvia gets through an open wound or mucous surface. With almost 99.8%, bites form the majority of the rabies trans- mission cases. Furthermore, faulty vaccines, aerosol transmission and corneal or other
Archives of Virology – Springer Journals
Published: Jun 1, 2005
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