Current status of viral expression systems in plants and perspectives for oral vaccines development

Current status of viral expression systems in plants and perspectives for oral vaccines development During the last 25 years, the technology to produce recombinant vaccines in plant cells has evolved from modest proofs of the concept to viable technologies adopted by some companies due to significant improvements in the field. Viral-based expression strategies have importantly contributed to this success owing to high yields, short production time (which is in most cases free of tissue culture steps), and the implementation of confined processes for production under GMPs. Herein the distinct expression systems based on viral elements are analyzed. This review also presents the outlook on how these technologies have been successfully applied to the development of plant-based vaccines, some of them being in advanced stages of development. Perspectives on how viral expression systems could allow for the development of innovative oral vaccines constituted by minimally-processed plant biomass are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Plant Molecular Biology Springer Journals

Current status of viral expression systems in plants and perspectives for oral vaccines development

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Publisher
Springer Netherlands
Copyright
Copyright © 2015 by Springer Science+Business Media Dordrecht
Subject
Life Sciences; Plant Sciences; Biochemistry, general; Plant Pathology
ISSN
0167-4412
eISSN
1573-5028
D.O.I.
10.1007/s11103-014-0279-5
Publisher site
See Article on Publisher Site

Abstract

During the last 25 years, the technology to produce recombinant vaccines in plant cells has evolved from modest proofs of the concept to viable technologies adopted by some companies due to significant improvements in the field. Viral-based expression strategies have importantly contributed to this success owing to high yields, short production time (which is in most cases free of tissue culture steps), and the implementation of confined processes for production under GMPs. Herein the distinct expression systems based on viral elements are analyzed. This review also presents the outlook on how these technologies have been successfully applied to the development of plant-based vaccines, some of them being in advanced stages of development. Perspectives on how viral expression systems could allow for the development of innovative oral vaccines constituted by minimally-processed plant biomass are discussed.

Journal

Plant Molecular BiologySpringer Journals

Published: Jan 6, 2015

References

  • Consistent gene silencing in transgenic plants expressing a replicating Potato virus X RNA
    Angell, SM; Baulcombe, DC
  • Jellyfish green fluorescent protein as a reporter for virus infections
    Baulcombe, D; Chapman, S; Santa Cruz, S
  • Transient expression of HPV16 E7 peptide (aa 44–60) and HPV16 L2 peptide (aa 108–120) on chimeric potyvirus-like particles using Potato virus X-based vector
    Čeřovská, N; Hoffmeisterová, H; Pecenková, T; Moravec, T; Synková, H; Plchová, H; Velemínský, J
  • Expression of a recombinant chimeric protein of hepatitis A virus VP1-Fc using a replicating vector based on Beet curly top virus in tobacco leaves and its immunogenicity in mice
    Chung, HY; Lee, HH; Kim, KI; Chung, HY; Hwang-Bo, J; Park, JH
  • In plant activation: an inducible, hyperexpression platform for recombinant protein production in plants
    Dugdale, B; Mortimer, CL; Kato, M; James, TA; Harding, RM; Dale, JL
  • Geminivirus strain demarcation and nomenclature
    Fauquet, CM; Briddon, RW; Brown, JK; Moriones, E; Stanley, J; Zerbini, M; Zhou, X
  • High-yield production of authentic human growth hormone using a plant virus-based expression system
    Gils, M; Kandzia, R; Marillonnet, S; Klimyuk, V; Gleba, Y
  • Viral vectors for the expression of proteins in plants
    Gleba, Y; Klimyuk, V; Marillonnet, S

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