Purpose of Review Infection in the setting of total joint arthroplasty, referred to as periprosthetic joint infection (PJI), is a devastating complication requiring prolonged and costly treatment. The unique environment around an artificial joint and ability of surrounding tissues to sequester bacteria collectively make prevention, diagnosis, and treatment of this condition challenging. In light of the unique pathogenesis of PJI, this review explores the limitations of contemporary treatments and discusses novel treatment options. Recent Findings Recent advancements in local antibiotic delivery platforms for preventing and treating PJI include titanium nanotube arrays, synthetic polymers, resorbable hydrogels, and cyclodextrin-based drug delivery options. In particular, cyclodextrins have facil- itated great advancements in other clinical disorders and have demonstrated early promise as a future option in the arena of PJI. Summary Novel treatment modalities for PJI optimize the implant surfaces to prevent bacterial biofilm formation or provide prolonged intra-articular antibiotic dosing to eradicate bacteria. . . . . . Keywords Periprosthetic joint infection Controlled antibiotic release Polymethylmethacrylate PMMA Calcium sulfate Cyclodextrin Introduction causative organism, treatment often involves prolonged systemic antibiotic therapy and multiple revision surgeries. Periprosthetic joint infection (PJI) following total joint Despite such rigorous treatment measures, PJI patients re- arthroplasty (TJA) is
Current Rheumatology Reports – Springer Journals
Published: Apr 30, 2018
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