Current Management of Liver Metastasis From Colorectal Cancer

Current Management of Liver Metastasis From Colorectal Cancer Purpose of Review To describe the main components of modern treatment for colorectal cancer (CRC) metastatic to the liver. Recent Findings Liver metastasis occurs in 50–60% of patients with CRC, and surgery is the only potentially curative treatment. Surgery should be performed where a complete (R0) resection of all radiologically visible metastases is possible. The presence of extra-hepatic disease no longer precludes liver metastectomy, and combined metastectomy in the liver and the extra-hepatic site can result in acceptable long-term survival. Peri-operative chemotherapy significantly improves PFS and DFS, but not OS. Modern cytotoxic regimens can convert a significant percentage of unresectable patients to resectable status, and the addition of biologic agents can increase the rate of conversion. Several local treatment modalities serve as alternatives, or sometimes as adjuncts, to resection of CRC liver metastasis and systemic chemotherapy. Summary The modern approach to CRC with liver metastasis combines surgery, modern cytotoxic and biologic agents, and modern technologies in the field of ablation, radiation, and endovascular access. The result is that long-term survival, and even cure, is now possible. . . Keywords Colorectal cancer Liver metastasis Overall survival Introduction median survival of 5–10 months without any treatment [11]. Recent studies report even http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Colorectal Cancer Reports Springer Journals

Current Management of Liver Metastasis From Colorectal Cancer

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Oncology; Proctology; Colorectal Surgery
ISSN
1556-3790
eISSN
1556-3804
D.O.I.
10.1007/s11888-018-0397-6
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review To describe the main components of modern treatment for colorectal cancer (CRC) metastatic to the liver. Recent Findings Liver metastasis occurs in 50–60% of patients with CRC, and surgery is the only potentially curative treatment. Surgery should be performed where a complete (R0) resection of all radiologically visible metastases is possible. The presence of extra-hepatic disease no longer precludes liver metastectomy, and combined metastectomy in the liver and the extra-hepatic site can result in acceptable long-term survival. Peri-operative chemotherapy significantly improves PFS and DFS, but not OS. Modern cytotoxic regimens can convert a significant percentage of unresectable patients to resectable status, and the addition of biologic agents can increase the rate of conversion. Several local treatment modalities serve as alternatives, or sometimes as adjuncts, to resection of CRC liver metastasis and systemic chemotherapy. Summary The modern approach to CRC with liver metastasis combines surgery, modern cytotoxic and biologic agents, and modern technologies in the field of ablation, radiation, and endovascular access. The result is that long-term survival, and even cure, is now possible. . . Keywords Colorectal cancer Liver metastasis Overall survival Introduction median survival of 5–10 months without any treatment [11]. Recent studies report even

Journal

Current Colorectal Cancer ReportsSpringer Journals

Published: Feb 8, 2018

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