Clin Exp Metastasis (2017) 34:363–364 DOI 10.1007/s10585-017-9866-6 EDITORIAL Rahul Jandial Published online: 14 November 2017 © Springer Science+Business Media B.V., part of Springer Nature 2017 Cancers that invade the brain are universally fatal. The cor- can be cured—even prevented. As we understand more about rosive nature of invasive cancers on the delicate neurologic the neural niche, it may become possible to design strategies framework generates harrowing neurologic deficits that to target the maladaptive metastatic mechanisms within this can be devastating on quality of life of our cancer patients. physiologic habitat. Despite significant advances in the diagnosis and manage- Metastatic cancers are known to demonstrate different ment of brain metastases, poor prognoses are inevitable even metabolic behavior compared to their primary counterparts. with when applying the best standard treatment strategies. While much is still needed to be known to undoubtedly con- This sobering fact is an ugly confession that we are still nect the mechanisms of biochemical metabolism to cerebral far from winning the battle against cancer metastasis in the metastasis, the ability to detect the accumulation or exhaus- central nervous system (CNS). tion of biochemical metabolites have been a topic of recent This special issue of Clinical and Experimental
Clinical & Experimental Metastasis – Springer Journals
Published: Nov 14, 2017
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