Purpose CT perfusion (CTP) imaging assessment of treatment response in advanced lung cancer can be compromised by respiratory motion. Our purpose was to determine whether an original motion correction method could improve the reproduc- ibility of such measurements. Materials and methods The institutional review board approved this prospective study. Twenty-one adult patients with non- resectable non-small-cell lung cancer provided written informed consent to undergo CTP imaging. A motion correction method that consisted of manually outlining the tumor margins and then applying a rigid manual landmark registration algorithm followed by the non-rigid diffeomorphic demons algorithm was applied. The non-motion-corrected and motion-corrected images were analyzed with dual blood supply perfusion analysis software. Two observers performed the analysis twice, and the intra- and inter-observer variability of each method was assessed with Bland-Altman statistics. Results The 95% limits of agreement of intra-observer reproducibility for observer 1 improved from −84.4%, 65.3% before motion correction to −33.8%, 30.3% after motion correction (r = 0.86 and 0.97, before and after motion correction, p <0.0001 for both) and for observer 2 from −151%, 96% to −49 %, 36 % (r = 0.87 and 0.95, p < 0.0001 for both). The 95% limits of agreement of inter-observer reproducibility
European Radiology – Springer Journals
Published: Jun 4, 2018
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