Mammalian Genome 10, 1115–1116 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Cross-species chromosome painting between human and marsupial directly demonstrates the ancient region of the mammalian X 1 1 2 2 3 Rob Glas, Jennifer A. Marshall Graves, Roland Toder, Malcolm Ferguson-Smith, Patricia C. O’Brien Department of Biochemistry and Genetics, LaTrobe University, Bundoora, Vic 3083, Australia Institute of Human Genetics and Anthropology, Freiburg i.Br. 79106, Germany Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK Received: 25 March 1999 / Accepted: 26 May 1999 Interspecies chromosome painting has been used to demonstrate phocytes from a human male. Chromosome painting was per- homologies between chromosomes of human and other primates formed under our usual conditions (Toder et al. 1997) with a 3-day (Wienberg et al. 1990), carnivores (Rettenberger et al. 1995), and hybridization time. The X Chr paint, labeled with P, was used to artiodactyls (Solinas-Toldo et al. 1995), which diverged about 60 probe a Southern blot containing wallaby and human DNA to million years before present (MyrBP). However, there has been no show that there was no DNA contaminant that could have influ- success in using the technique for wider comparisons, for instance enced the
Mammalian Genome – Springer Journals
Published: Nov 1, 1999
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