Crizotinib Reactions 1680, p100 - 2 Dec 2017 ALK G1269A mutation leading to crizotinib resistance: case report In a retrospective study of 8 patients, a 29-year-old man developed drug resistance due to ALK G1269A mutation during treatment with crizotinib [route, dosages not stated]. He had a diagnosis of stage IV non-small-cell lung cancer (NSCLC) and he received anaplastic lymphoma kinase (ALK) inhibitor therapy. Initially, he received crizotinib therapy, which was followed by ceritinib therapy. During the crizotinib therapy, he developed ALK G1269A mutation, which led to the resistance of ALK inhibitor therapy [duration of treatment to reaction onset not stated]. On the ceritinib therapy, he had a remission of only 3 months. After this, his disease progressed with the pleural effusion and mediastinal lymph nodes development [reaction outcome not stated]. Author comment: "One patient, who experienced PD during alectinib treatment, had ALK G1269A mutation (patient 4). The G1269A mutation is reported to confer resistance to crizotinib while conferring sensitivity to alectinib and ceritinib; in this case, treatment with crizotinib before ceritinib treatment might affect G1269A mutation expression." Oya Y, et al. Clinical efficacy of alectinib in patients with ALK-rearranged non- small cell lung cancer after ceritinib failure. Anticancer Research 37: 6477-6480, No. 11, Nov 2017. Available from: URL: - Japan 803284654 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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