Crizotinib Reactions 1680, p101 - 2 Dec 2017 Development of acquired resistance due to acquired PIK3CA gene mutation: case report An elderly woman in her 60s [specific age at the time of reaction onset not stated] developed acquired resistance to crizotinib due to acquired PIK3CA gene mutation during treatment for lung adenocarcinoma [dosage and outcome not stated]. The woman was diagnosed with stage IIIB lung adenocarcinoma, on 13 April 2015. Subsequently, she received chemotherapy with various drugs including pemetrexed, carboplatin and bevacizumab. A CT scan revealed progression of the pulmonary lesions, on 20 November 2015. A next generation sequencing was performed on her blood sample, which demonstrated CD74-ROS1 fusion, a variant of the ROS1 translocation, and C176F and G245S mutation in TP53 gene. She was started on oral crizotinib, on 20 January 2016. A repeated CT scan showed a partial response of her pulmonary lesions, on 03 March 2016. However, she experienced chest tightness and shortness of breath, in June 2016. A CT scan performed on 08 July 2016 demonstrated rapid progression of the pulmonary lesions indicative of an acquired resistance to crizotinib. A subsequent next generation sequencing was performed on her blood samples, which revealed a novel point mutation of L531P type of the PIK3CA gene. The novel point mutation of the PIK3CA gene activated the mTOR signalling pathway. Considering this activation, the woman was treated with everolimus. However, disease progression was substantially significant by this time. She eventually died due to circulatory failure on 16 August 2016. Author comment: "The patient reported herein was diagnosed with lung adenocarcinoma and harbored a ROS1 rearrangement. She initially showed a response to crizotinib treatment, but the disease ultimately progressed. We identified an acquired mutation in her blood that led to mTOR pathway activation, which conferred resistance to Xu C-W, et al. Patient harboring a novel PIK3CA point mutation after acquired resistance to crizotinib in an adenocarcinoma with ROS1 rearrangement: A case report and literature review. Thoracic Cancer 8: 714-719, No. 6, Nov 2017. Available from: URL: - China 803285262 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
1 page

Loading next page...
1 Page
Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial