Crizotinib Reactions 1680, p99 - 2 Dec 2017 ALK and KRAS mutations leading to acquired crizotinib resistance: 12 case reports In a study of 20 patients, 12 patients (eight women and four men) aged between 40–81 years were described, who developed anaplastic lymphoma kinase (ALK; n=5) and Kirsten rat sarcoma (KRAS; n=10) gene mutations leading to acquired crizotinib resistance [routes and dosages not stated]. The patients had a history of advanced ALK-positive non small cell lung cancer (NSCLC) and started receiving treatment with tyrosine kinase inhibitor (TKI), crizotinib. The patients experienced disease progression at different site like lymph node (n=3), brain (n=9), liver (n=2), lung (n=2) and pleura (n=2). Subsequent investigations revealed development of ALK and KRAS gene mutations which conferred the resistance. The patients started receiving treatment with chemotherapy (one patient), brigatinib (n=9) and ceritinib (one patient). The disease was stable in three of the 12 patients. Disease progression was observed in another three patients [not all outcomes stated]. Author comment: "To our knowledge, this is the first report to evaluate the acquired resistance to ALK-TKIs using cfDNA in a cohort of crizotinib-resistant NSCLC patients." Bordi P, et al. Detection of ALK and KRAS Mutations in Circulating Tumor DNA of Patients With Advanced ALK-Positive NSCLC With Disease Progression During Crizotinib Treatment. Clinical Lung Cancer 18: 692-697, No. 6, Nov 2017. Available from: URL: - Italy 803284377 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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