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CRISPR-based diagnostics

CRISPR-based diagnostics research highlights DIAGNOSTICS INFeCTIOuS DISeASe brain-resident innate immune cells called Zika virus shedding in semen microglia and results in altered later Science 360, 436–439 (2018) development of neuropathologies in mice. N. Engl. J. Med. 378, 1377–1385 (2018) Science 360, 439–444 (2018) Previous exposure of myeloid cells to Zika virus RNA is commonly shed in the immune stimuli can result in immune training, Science 360, 444–448 (2018) semen of infected men, and in some of in which subsequent immune responses are these men, this occurs beyond 6 months Sensitive, specific and portable diagnostics exacerbated, or immune tolerance, in which can rapidly identify viral infections. after the first appearance of symptoms. later immune responses are inhibited. Shedding of infectious virus, however, Quick and reliable diagnosis of viral disease Wendeln et al. found that exposing a in the field can aid treatment and containment. appears to be limited to the month mouse engineered to develop Alzheimer’s immediately after illness onset. The recently developed specific high-sensitivity disease pathology to a peripheral immune enzymatic reporter unlocking platform Zika virus is transmitted by mosquitoes stimulus that results in immune training and during recent outbreaks has been (SHERLOCK) is based on the programmable increased Alzheimer’s neuropathology, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Medicine Springer Journals

CRISPR-based diagnostics

Stower, Hannah
Nature Medicine , Volume 24 (6) – Jun 6, 2018
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CRISPR-based diagnostics

Abstract

research highlights DIAGNOSTICS INFeCTIOuS DISeASe brain-resident innate immune cells called Zika virus shedding in semen microglia and results in altered later Science 360, 436–439 (2018) development of neuropathologies in mice. N. Engl. J. Med. 378, 1377–1385 (2018) Science 360, 439–444 (2018) Previous exposure of myeloid cells to Zika virus RNA is commonly shed in the immune stimuli can result in immune training, Science 360, 444–448 (2018) semen of infected men,...
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Publisher
Springer Journals
Copyright
Copyright © 2018 by The Publisher
Subject
Biomedicine; Biomedicine, general; Cancer Research; Metabolic Diseases; Infectious Diseases; Molecular Medicine; Neurosciences
ISSN
1078-8956
eISSN
1546-170X
DOI
10.1038/s41591-018-0073-z
Publisher site
See Article on Publisher Site

Abstract

research highlights DIAGNOSTICS INFeCTIOuS DISeASe brain-resident innate immune cells called Zika virus shedding in semen microglia and results in altered later Science 360, 436–439 (2018) development of neuropathologies in mice. N. Engl. J. Med. 378, 1377–1385 (2018) Science 360, 439–444 (2018) Previous exposure of myeloid cells to Zika virus RNA is commonly shed in the immune stimuli can result in immune training, Science 360, 444–448 (2018) semen of infected men, and in some of in which subsequent immune responses are these men, this occurs beyond 6 months Sensitive, specific and portable diagnostics exacerbated, or immune tolerance, in which can rapidly identify viral infections. after the first appearance of symptoms. later immune responses are inhibited. Shedding of infectious virus, however, Quick and reliable diagnosis of viral disease Wendeln et al. found that exposing a in the field can aid treatment and containment. appears to be limited to the month mouse engineered to develop Alzheimer’s immediately after illness onset. The recently developed specific high-sensitivity disease pathology to a peripheral immune enzymatic reporter unlocking platform Zika virus is transmitted by mosquitoes stimulus that results in immune training and during recent outbreaks has been (SHERLOCK) is based on the programmable increased Alzheimer’s neuropathology,

Journal

Nature Medicine – Springer Journals

Published: Jun 6, 2018

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