Creation of live influenza vaccines with the use of site-specific mutagenesis

Creation of live influenza vaccines with the use of site-specific mutagenesis The introduction of genetic engineering methods into the production of live influenza vaccines provides significant optimization of separate stages of this process. In recent years, special attention has been paid to a method based on the direct incorporation of well-known and well-studied mutations into the genome of epidemic variants of influenza virus. Such virus obtains the ts- and att phenotypes and can be used for the production of live influenza vaccines. The article discusses the applications of this approach and problems associated with its use in medical and veterinary vaccinology. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biology Bulletin Reviews Springer Journals

Creation of live influenza vaccines with the use of site-specific mutagenesis

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Publisher
Pleiades Publishing
Copyright
Copyright © 2017 by Pleiades Publishing, Ltd.
Subject
Life Sciences; Life Sciences, general; Cell Biology; Biochemistry, general; Zoology; Ecology
ISSN
2079-0864
eISSN
2079-0872
D.O.I.
10.1134/S2079086417040065
Publisher site
See Article on Publisher Site

Abstract

The introduction of genetic engineering methods into the production of live influenza vaccines provides significant optimization of separate stages of this process. In recent years, special attention has been paid to a method based on the direct incorporation of well-known and well-studied mutations into the genome of epidemic variants of influenza virus. Such virus obtains the ts- and att phenotypes and can be used for the production of live influenza vaccines. The article discusses the applications of this approach and problems associated with its use in medical and veterinary vaccinology.

Journal

Biology Bulletin ReviewsSpringer Journals

Published: Aug 23, 2017

References

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