Creatinine Versus Cystatin C: Differing Estimates of Renal Function in Hospitalized Veterans Receiving Anticoagulants

Creatinine Versus Cystatin C: Differing Estimates of Renal Function in Hospitalized Veterans... Creatinine Versus Cystatin C: Differing Estimates of Renal Function in Hospitalized Veterans Receiving Anticoagulants 1,2 3 1 Christina Hao Wang, MD , Anna D. Rubinsky, PhD , Tracy Minichiello, MD , 1,2,3,4 1,2 Michael G. Shlipak, MD, MPH , and Erika Leemann Price, MD, MPH 1 2 San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco (UCSF), 3 4 San Francisco, CA, USA; Kidney Health Research Collaborative, UCSF and SFVAMC, San Francisco, CA, USA; Department of Epidemiology & Biostatistics, UCSF, San Francisco, CA, USA. patients were reclassified into lower drug-dosing catego- BACKGROUND: Current practice in anticoagulation dos- ries using cystatin C compared to creatinine-based ing relies on kidney function estimated by serum creati- estimates. nine using the Cockcroft-Gault equation. However, creat- CONCLUSIONS: We found substantial discordance in inine can be unreliable in patients with low or high muscle eGFR comparing cystatin C with creatinine in this group mass. Cystatin C provides an alternative estimation of of anticoagulated inpatients. Our sample size was limited glomerular filtration rate (eGFR) that is independent of and included few women. Further investigation is needed muscle. to confirm these findings and evaluate implications for OBJECTIVE: We http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of General Internal Medicine Springer Journals

Creatinine Versus Cystatin C: Differing Estimates of Renal Function in Hospitalized Veterans Receiving Anticoagulants

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Society of General Internal Medicine (This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply)
Subject
Medicine & Public Health; Internal Medicine
ISSN
0884-8734
eISSN
1525-1497
D.O.I.
10.1007/s11606-018-4461-3
Publisher site
See Article on Publisher Site

Abstract

Creatinine Versus Cystatin C: Differing Estimates of Renal Function in Hospitalized Veterans Receiving Anticoagulants 1,2 3 1 Christina Hao Wang, MD , Anna D. Rubinsky, PhD , Tracy Minichiello, MD , 1,2,3,4 1,2 Michael G. Shlipak, MD, MPH , and Erika Leemann Price, MD, MPH 1 2 San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco (UCSF), 3 4 San Francisco, CA, USA; Kidney Health Research Collaborative, UCSF and SFVAMC, San Francisco, CA, USA; Department of Epidemiology & Biostatistics, UCSF, San Francisco, CA, USA. patients were reclassified into lower drug-dosing catego- BACKGROUND: Current practice in anticoagulation dos- ries using cystatin C compared to creatinine-based ing relies on kidney function estimated by serum creati- estimates. nine using the Cockcroft-Gault equation. However, creat- CONCLUSIONS: We found substantial discordance in inine can be unreliable in patients with low or high muscle eGFR comparing cystatin C with creatinine in this group mass. Cystatin C provides an alternative estimation of of anticoagulated inpatients. Our sample size was limited glomerular filtration rate (eGFR) that is independent of and included few women. Further investigation is needed muscle. to confirm these findings and evaluate implications for OBJECTIVE: We

Journal

Journal of General Internal MedicineSpringer Journals

Published: May 31, 2018

References

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