COX2 induction: a mechanism of endocrine breast cancer resistance?

COX2 induction: a mechanism of endocrine breast cancer resistance? Breast Cancer Res Treat (2017) 165:383–389 DOI 10.1007/s10549-017-4284-7 CLINICAL TRIAL COX2 induction: a mechanism of endocrine breast cancer resistance? 1 2 1,3 • • Brandi L. Clark Michael A. Murphy Landry K. Kamdem Received: 1 April 2017 / Accepted: 4 May 2017 / Published online: 21 June 2017 Springer Science+Business Media New York 2017 Abstract administration. We found no statistically significant cor- Purpose Urine prostaglandin E2 (PGE2) levels have relations between fold increase in urine PGE2 levels and shown to be a risk factor of breast cancer, and the use of the pharmacokinetics of either exemestane or 17-hy- nonsteroidal anti-inflammatory drugs (NSAIDs) is known droexemestane (major in vivo metabolite of exemestane). to be beneficial in preventing breast cancer risk and/or Conclusion Our results indicate that one of the pharma- recurrence with or without aromatase inhibitors. We cological effects to aromatase inhibitors (e.g., exemestane) hypothesized that the use of an aromatase inhibitor triggers involves the activation of the inflammatory pathway via the activation of the inflammatory pathway via release of release of PGE2. Further in vitro mechanistic and in vivo PGE2. translational studies designed to elucidate the role of this Methods A single oral 25 mg dose of an aromatase http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Breast Cancer Research and Treatment Springer Journals

COX2 induction: a mechanism of endocrine breast cancer resistance?

Loading next page...
 
/lp/springer_journal/cox2-induction-a-mechanism-of-endocrine-breast-cancer-resistance-rINt3o6RPW
Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media New York
Subject
Medicine & Public Health; Oncology
ISSN
0167-6806
eISSN
1573-7217
D.O.I.
10.1007/s10549-017-4284-7
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial