PharmacoEconomics & Outcomes News 804, p12 - 2 Jun 2018
Costs of interventions to increase
A cost function has been developed to support
decisions on investments in interventions to increase
immunisation coverage, report authors of a systematic
review published in Vaccine.
Investigators conducted a systematic review of
English-language, peer-reviewed studies published in
PubMed up to March 2017 which reported the costs and
effectiveness of interventions for increasing
immunisation coverage. Many studies reported the
effectiveness of interventions but failed to provide cost
data. A total of 42 studies assessing 56 interventions met
the inclusion criteria.
A cost function was developed to estimate the non-
vaccine cost per dose of interventions to increase
immunisation coverage by one percent, through
campaigns or routine immunisation in low- and high-
The interventions involved vaccine delivery methods
in 36% of studies. Overall, 64% and 36% of interventions
were aimed at increasing vaccination coverage for
multiple antigens and single antigens, respectively, and
53% of interventions targeted multiple vaccines.
The intervention cost per dose per percent increase in
immunisation coverage ranged from $0.01
(mean $3.13), and increased with higher baseline
coverage rates. The mean cost was $0.06 and $3.56 in
low- and high-income countries, respectively.
"The cost function presented here should inform
country immunization stakeholders, international
donors, and national immunization technical advisory
groups as they estimate the resources needed to
increase immunization coverage," said the authors.
* 2016 US dollars
Ozawa S, et al. Systematic review of the incremental costs of interventions that
increase immunization coverage. Vaccine : 10 May 2018. Available from: URL:
PharmacoEconomics & Outcomes News 2 Jun 2018 No. 8041173-5503/18/0804-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved