Cost-effectiveness analysis of laparoscopic versus open surgery in colon cancer

Cost-effectiveness analysis of laparoscopic versus open surgery in colon cancer Background Few economic evaluations have assessed laparoscopy for colon cancer. This study aimed to compare the cost- effectiveness of laparoscopic and open surgery for the treatment of colon cancer. Method A cost-effectiveness analysis was performed comparing two groups of patients treated according to standard clini- cal practice (REDISSEC-CARESS/CCR cohort) by laparoscopic or open surgery. Data were collected from health records on clinical characteristics and resource use over 2 years after surgery. To calculate the incremental cost-effectiveness ratio, costs and quality-adjusted life years (QALYs) were obtained for each patient. Clinical heterogeneity was addressed using propensity score and joint multivariable analysis (seemingly unrelated regression) that included interactions between TNM stage, age, and surgical procedure to perform subgroup analysis. Results The sample was composed of 1591 patients, 963 who underwent laparoscopy and 628 open surgery. Using propensity score and regression analysis, we found that laparoscopy was associated with more QALYs and less resource use than open surgery (0.0163 QALYs, 95% CI 0.0114–0.0212; and − €3461, 95% CI − 3337 to − 3586). Costs were lower for laparoscopy in all subgroups. In the subgroups younger than 80 years old, utility was higher in patients who underwent laparoscopy. Nevertheless, open surgery had better outcomes in older http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Surgical Endoscopy Springer Journals

Cost-effectiveness analysis of laparoscopic versus open surgery in colon cancer

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Surgery; Gynecology; Gastroenterology; Hepatology; Proctology; Abdominal Surgery
ISSN
0930-2794
eISSN
1432-2218
D.O.I.
10.1007/s00464-018-6250-9
Publisher site
See Article on Publisher Site

Abstract

Background Few economic evaluations have assessed laparoscopy for colon cancer. This study aimed to compare the cost- effectiveness of laparoscopic and open surgery for the treatment of colon cancer. Method A cost-effectiveness analysis was performed comparing two groups of patients treated according to standard clini- cal practice (REDISSEC-CARESS/CCR cohort) by laparoscopic or open surgery. Data were collected from health records on clinical characteristics and resource use over 2 years after surgery. To calculate the incremental cost-effectiveness ratio, costs and quality-adjusted life years (QALYs) were obtained for each patient. Clinical heterogeneity was addressed using propensity score and joint multivariable analysis (seemingly unrelated regression) that included interactions between TNM stage, age, and surgical procedure to perform subgroup analysis. Results The sample was composed of 1591 patients, 963 who underwent laparoscopy and 628 open surgery. Using propensity score and regression analysis, we found that laparoscopy was associated with more QALYs and less resource use than open surgery (0.0163 QALYs, 95% CI 0.0114–0.0212; and − €3461, 95% CI − 3337 to − 3586). Costs were lower for laparoscopy in all subgroups. In the subgroups younger than 80 years old, utility was higher in patients who underwent laparoscopy. Nevertheless, open surgery had better outcomes in older

Journal

Surgical Endoscopy – Springer Journals

Published: Jun 4, 2018

References

  • Worldwide variations in colorectal cancer
    Center, MM; Jemal, A; Smith, RA; Ward, E
  • Colorectal cancer: national and international perspective on the burden of disease and public health impact
    Gellad, ZF; Provenzale, D
  • Clinical effectiveness and cost-effectiveness of laparoscopic surgery for colorectal cancer: systematic reviews and economic evaluation
    Murray, A; Lourenco, T; Verteuil, R; Hernandez, R; Fraser, C; McKinley, A; Krukowski, Z; Vale, L; Grant, A
  • Cost-effectiveness of laparoscopic vs open resection for colon and rectal cancer
    Jensen, CC; Prasad, LM; Abcarian, H
  • Randomized clinical trial of laparoscopic versus open left colonic resection
    Braga, M; Frasson, M; Zuliani, W; Vignali, A; Pecorelli, N; Carlo, V
  • Short term benefits for laparoscopic colorectal resection
    Schwenk, W; Haase, O; Neudecker, J; Müller, JM
  • Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomized trial
    Veldkamp, R; Kuhry, E; Hop, WC; Jeekel, J; Kazemier, G; Bonjer, HJ; Haglind, E; Påhlman, L; Cuesta, MA; Msika, S; Morino, M; Lacy, AM
  • Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial
    Leung, KL; Kwok, SP; Lam, SC; Lee, JF; Yiu, RY; Ng, SS; Lai, PB; Lau, WY
  • Case-matched comparison of clinical and financial outcome after laparoscopic or open colorectal surgery
    Delaney, CP; Kiran, RP; Senagore, AJ; Brady, K; Fazio, VW
  • Survival analysis for economic evaluations alongside clinical trials–extrapolation with patient-level data: inconsistencies, limitations, and a practical guide
    Latimer, NR
  • Methodological issues in the economic analysis of cancer treatments
    Tappenden, P; Chilcott, J; Ward, S; Eggington, S; Hind, D; Hummel, S
  • Are policy decisions on surgical procedures informed by robust economic evidence? A systematic review
    Ara, R; Basarir, H; Keetharuth, AD; Barbieri, M; Weatherly, HL; Sculpher, MJ; Ahmed, H; Brown, S
  • Economics and the laparoscopic surgery learning curve: comparison with open surgery for rectosigmoid cancer
    Park, JS; Kang, SB; Kim, SW; Cheon, GN
  • Colorectal cancer health services research study protocol: the CCR-CARESS observational prospective cohort project
    Quintana, JM; Gonzalez, N; Anton-Ladislao, A; Redondo, M; Bare, M; Fernandez de Larrea, N; Briones, E; Escobar, A; Sarasqueta, C; Garcia-Gutierrez, S; Aguirre, U
  • Randomized, controlled trials, observational studies, and the hierarchy of research designs
    Concato, J; Shah, N; Horwitz, RI
  • A comparison of observational studies and randomized, controlled trials
    Benson, K; Hartz, AJ
  • From randomized controlled trials to observational studies
    Silverman, SL
  • Variations in cancer survival and patterns of care across Europe: roles of wealth and health-care organization
    Gatta, G; Trama, A; Capocaccia, R
  • Using real-world data for coverage and payment decisions: the ISPOR real-world data task force report
    Garrison, LP; Neumann, PJ; Erickson, P; Marshall, D; Mullins, CD
  • Methods for the economic evaluation of health care programmes
    Drummond, MF; Sculpher, MJ; Torrance, GW
  • Cost-effectiveness in health and medicine
    Gold, M; Siegel, JE; Russell, LB; Weinstein, MC
  • The Spanish version of EuroQol: a description and its applications. European Quality of Life scale
    Badia, X; Roset, M; Montserrat, S; Herdman, M; Segura, A
  • Economic evaluation in clinical trials
    Glick, HA; Doshi, JA; Sonnad, SS; Polsky, D
  • Cost-utility analysis of an integrated care model for multimorbid patients based on a clinical trial
    Lanzeta, I; Mar, J; Arrospide, A
  • An introduction to propensity score methods for reducing the effects of confounding in observational studies
    Austin, PC
  • Genetic matching for estimating causal effects: a general multivariate matching method for achieving balance in observational studies
    Diamond, A; Sekhon, JS
  • Generalized linear models and extensions
    Hardin, J; Hilbe, J
  • Statistical analysis of cost-effectiveness data
    Willan, AR; Briggs, AH
  • Estimating mean QALYs in trial-based cost-effectiveness analysis: the importance of controlling for baseline utility
    Manca, A; Hawkins, N; Sculpher, MJ
  • Laparoscopic surgery for colorectal cancer in patients over 80 years of age: the morbidity outcomes
    Lim, SW; Kim, YJ; Kim, HR
  • Evaluation of short-term outcomes of laparoscopic-assisted surgery for colorectal cancer in elderly patients aged over 75 years old: a multi-institutional study (YSURG1401)
    Kazama, K; Aoyama, T; Hayashi, T; Yamada, T; Numata, M; Amano, S; Kamiya, M; Sato, T; Yoshikawa, T; Shiozawa, M; Oshima, T; Yukawa, N; Rino, Y; Masuda, M
  • Cost-effectiveness of laparoscopy in rectal cancer
    Keller, DS; Champagne, BJ; Reynolds, HL; Stein, SL; Delaney, CP
  • Hospital costs of colorectal cancer surgery for the oldest old: a Dutch population-based study
    Govaert, JA; Govaert, MJ; Fiocco, M; Dijk, WA; Tollenaar, RA; Wouters, MW
  • Colon cancer surgery: a retrospective study based on a large administrative database
    Saia, M; Buja, A; Mantoan, D; Agresta, F; Baldo, V
  • Cost-effectiveness of haemorrhoidal artery ligation versus rubber band ligation for the treatment of grade II-III haemorrhoids: analysis using evidence from the HubBLe trial
    Alshreef, A; Wailoo, AJ; Brown, SR; Tiernan, JP; Watson, AJM; Biggs, K; Bradburn, M; Hind, D
  • How does a shared decision-making (SDM) intervention for oncologists affect participation style and preference matching in patients with breast and colon cancer?
    Bieber, C; Nicolai, J; Gschwendtner, K; Müller, N; Reuter, K; Buchholz, A; Kallinowski, B; Härter, M; Eich, W
  • Preoperative risk information and patient involvement in surgical treatment for rectal and sigmoid cancer
    Snijders, HS; Kunneman, M; Bonsing, BA; Vries, AC; Tollenaar, RA; Pieterse, AH; Stiggelbout, AM
  • Effect of first-line chemotherapy combined with cetuximab or bevacizumab on overall survival in patients with KRAS wild-type advanced or metastatic colorectal cancer: a randomized clinical trial
    Venook, AP; Niedzwiecki, D; Lenz, HJ; Innocenti, F; Fruth, B; Meyerhardt, JA; Schrag, D; Greene, C; O’Neil, BH; Atkins, JN; Berry, S; Polite, BN; O’Reilly, EM; Goldberg, RM; Hochster, HS; Schilsky, RL; Bertagnolli, MM; El-Khoueiry, AB; Watson, P; Benson, AB; Mulkerin, DL; Mayer, RJ; Blanke, C
  • Comparison of approaches for estimating incidence costs of care for colorectal cancer patients
    Yabroff, KR; Warren, JL; Schrag, D; Mariotto, A; Meekins, A; Topor, M; Brown, ML
  • Oncologic outcomes following laparoscopic versus open resection of pT4 colon cancer: a systematic review and meta-analysis
    Feinberg, AE; Chesney, TR; Acuna, SA; Sammour, T; Quereshy, FA
  • Longterm results of laparoscopic colorectal cancer resection
    Kuhry, E; Schwenk, WF; Gaupset, R; Romild, U; Bonjer, HJ

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